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  Sleep-active neuron specification and sleep induction require FLP-11 neuropeptides to systemically induce sleep.

Turek, M., Besseling, J., Spies, J. P., König, S., & Bringmann, H. (2016). Sleep-active neuron specification and sleep induction require FLP-11 neuropeptides to systemically induce sleep. eLife, 5: e12499. doi:10.7554/eLife.12499.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-1C36-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-2686-B
Genre: Journal Article

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Turek, M.1, Author              
Besseling, J.1, Author              
Spies, J. P.1, Author              
König, S.1, Author              
Bringmann, H.1, Author              
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1Research Group of Sleep and Waking, MPI for Biophysical Chemistry, Max Planck Society, ou_578607              

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 Abstract: Sleep is an essential behavioral state. It is induced by conserved sleep-active neurons that express GABA. However, little is known about how sleep neuron function is determined and how sleep neurons change physiology and behavior systemically. Here, we investigated sleep in Caenorhabditis elegans, which is induced by the single sleep-active neuron RIS. We found that the transcription factor LIM-6, which specifies GABAergic function, in parallel determines sleep neuron function through the expression of APTF-1, which specifies the expression of FLP-11 neuropeptides. Surprisingly FLP-11, and not GABA, is the major component that determines the sleep-promoting function of RIS. FLP-11 is constantly expressed in RIS. At sleep onset RIS depolarizes and releases FLP-11 to induce a systemic sleep state.

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Language(s): eng - English
 Dates: 2016-03-07
 Publication Status: Published online
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 Rev. Method: Peer
 Identifiers: DOI: 10.7554/eLife.12499
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Title: eLife
Source Genre: Journal
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Pages: 18 Volume / Issue: 5 Sequence Number: e12499 Start / End Page: - Identifier: -