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  ZnO-based nanoplatforms for labeling and treatment of mouse tumors without detectable toxic side effects

Ye, D.-X., Ma, Y.-Y., Zhao, W., Cao, H.-M., Kong, J.-L., Xiong, H.-M., et al. (2016). ZnO-based nanoplatforms for labeling and treatment of mouse tumors without detectable toxic side effects. ACS Nano, 10(4), 4294-4300. doi:10.1021/acsnano.5b07846.

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 Creators:
Ye, Dai-Xin, Author
Ma, Ying-Ying, Author
Zhao, Wei, Author
Cao, Hong-Mei, Author
Kong, Ji-Lie, Author
Xiong, Huan-Ming, Author
Möhwald, Helmuth1, Author              
Affiliations:
1Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863284              

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Free keywords: ZnO, anticancer, drug delivery, fluorescent imaging, magnetic resonance imaging
 Abstract: ZnO quantum dots (QDs) were synthesized with polymer shells, coordinated with Gd3+ ions and adsorbed doxorubicin (DOX) together to form a new kind of multifunctional ZnO-Gd-DOX nanoplatform. Such pH sensitive nanoplatforms were shown to release DOX to cancer cells in vitro and to mouse tumors in vivo, and reveal better specificity and lower toxicity than free DOX, and even better therapeutic efficacy than an FDA approved commercial DOX-loading drug DOX-Liposome Injection (DOXIL, NDA#050718). The ZnO-Gd-DOX nanoplatforms exhibited strong red fluorescence, which benefited the fluorescent imaging on live mice. Due to the special structure of ZnO-Gd-DOX nanoparticles, such nanoplatforms possessed a high longitudinal relaxivity r1 of 52.5 mM?1 s?1 at 0.55 T, which was superior to many other Gd3+ based nanoparticles. Thus, both fluorescence labeling and magnetic resonance imaging could be applied simultaneously on the tumor bearing mice along with drug delivery. After 36 days of treatment on these mice, ZnO-Gd-DOX nanoparticles greatly inhibited the tumor growth without causing any appreciable abnormality in major organs. The most important merit of ZnO-Gd-DOX was that such a nanoplatform was biodegraded completely and showed no toxic side effects after H&E (hematoxylin and eosin) staining of tumor slices and ICP-AES (inductively coupled plasma atomic emission spectrometry) bioanalyses.

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 Dates: 2016-03-242016
 Publication Status: Published in print
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 Identifiers: DOI: 10.1021/acsnano.5b07846
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Title: ACS Nano
Source Genre: Journal
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Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 10 (4) Sequence Number: - Start / End Page: 4294 - 4300 Identifier: ISSN: 1936-0851