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  Restarting life: Fertilization and the transition from meiosis to mitosis.

Clift, D., & Schuh, M. (2013). Restarting life: Fertilization and the transition from meiosis to mitosis. Nature Reviews Molecular Cell Biology, 14(9), 549-562. doi:10.1038/nrm3643.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-1F62-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-201D-0
Genre: Journal Article

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 Creators:
Clift, D., Author
Schuh, M.1, Author              
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1Department of Meiosis, MPI for Biophysical Chemistry, Max Planck Society, ou_2205654              

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 Abstract: Fertilization triggers a complex cellular programme that transforms two highly specialized meiotic germ cells, the oocyte and the sperm, into a totipotent mitotic embryo. Linkages between sister chromatids are remodelled to support the switch from reductional meiotic to equational mitotic divisions; the centrosome, which is absent from the egg, is reintroduced; cell division shifts from being extremely asymmetric to symmetric; genomic imprinting is selectively erased and re-established; and protein expression shifts from translational control to transcriptional control. Recent work has started to reveal how this remarkable transition from meiosis to mitosis is achieved.

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Language(s): eng - English
 Dates: 2013-08-14
 Publication Status: Published online
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 Rev. Method: Peer
 Identifiers: DOI: 10.1038/nrm3643
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Title: Nature Reviews Molecular Cell Biology
Source Genre: Journal
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Pages: - Volume / Issue: 14 (9) Sequence Number: - Start / End Page: 549 - 562 Identifier: -