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  Structural aspects of phenylglycines, their biosynthesis and occurrence in peptide natural products

Toma, R. S. A., Brieke, C., Cryle, M. J., & Süssmuth, R. D. (2015). Structural aspects of phenylglycines, their biosynthesis and occurrence in peptide natural products. Natural Product Reports, 32(8), 1207-1235. doi:10.1039/C5NP00025D.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-21C6-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-21C7-8
Genre: Journal Article

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NatProdRep_32_2015_1207.pdf (Any fulltext), 3MB
 
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 Creators:
Toma, Rashed S. Al, Author
Brieke, Clara1, Author              
Cryle, Max J.1, Author              
Süssmuth, Roderich D., Author
Affiliations:
1Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society, ou_1497700              

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 Abstract: Phenylglycine-type amino acids occur in a wide variety of peptide natural products, including glycopeptide antibiotics and biologically active linear and cyclic peptides. Sequencing of biosynthesis gene clusters of chloroeremomycin, balhimycin and pristinamycin paved the way for intensive investigations on the biosynthesis of 4-hydroxyphenylglycine (Hpg), 3,5-dihydroxyphenylglycine (Dpg) and phenylglycine (Phg) in recent years. The significance and importance of this type of unusual non-proteinogenic aromatic amino acids also for medicinal chemistry has drawn the attention of many research groups and pharmaceutical companies. Herein structures and properties of phenylglycine containing natural products as well as the biosynthetic origin and incorporation of phenylglycines are discussed.

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Language(s): eng - English
 Dates: 2015-02-252015-08-01
 Publication Status: Published in print
 Pages: 29
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
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Title: Natural Product Reports
Source Genre: Journal
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Publ. Info: Cambridge, England : Royal Society of Chemistry
Pages: - Volume / Issue: 32 (8) Sequence Number: - Start / End Page: 1207 - 1235 Identifier: ISSN: 0265-0568
CoNE: https://pure.mpg.de/cone/journals/resource/110978977979506