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  Receptor-induced transient responses in cells with oscillatory actin dynamics

Negrete Jr., J., Pumir, A., Westendorf, C., Tarantola, M., Bodenschatz, E., & Beta, C. (2020). Receptor-induced transient responses in cells with oscillatory actin dynamics. Physical Review Research, 2(1): 013239. doi:10.1103/PhysRevResearch.2.013239.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-28A2-F Version Permalink: http://hdl.handle.net/21.11116/0000-0006-AB5F-0
Genre: Journal Article

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Negrete Jr., Jose1, Author              
Pumir, Alain1, Author              
Westendorf, Christian1, Author              
Tarantola, Marco1, Author              
Bodenschatz, Eberhard1, Author              
Beta, Carsten1, Author              
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1Laboratory for Fluid Dynamics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2063287              

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 Abstract: Living cells adjust their sensing and migratory machinery in response to changes in their environment. In this work, we show that cells of the social amoeba Dictyostelium discoideum modulate the dynamical state of their actin cytoskeleton in response to an external pulse of the chemoattractant cyclic adenosine monophosphate (cAMP). In particular, we focus on a population of cells that exhibits noisy oscillatory cycles of actin polymerization and systematically study receptor-induced transitions in their cytoskeletal dynamics. In response to a short external pulse of cAMP, these cells adopt a noisy quiescent state, before returning to their initial, oscillatory dynamics. The response exhibits a biphasic time profile, with a duration that shows strong variability between cells; it can extend as long as approximately twelve oscillation cycles. We propose a model that is based on a generic nonlinear noisy oscillator. Our theoretical analysis suggests that the transient termination of oscillations in response to a receptor stimulus occurs via a Hopf bifurcation.

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Language(s): eng - English
 Dates: 2020-03-022020-03
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1103/PhysRevResearch.2.013239
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Title: Physical Review Research
Source Genre: Journal
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Pages: 18 Volume / Issue: 2 (1) Sequence Number: 013239 Start / End Page: - Identifier: -