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  Long noncoding RNAs in organogenesis: Making the difference

Grote, P., & Herrmann, B. G. (2015). Long noncoding RNAs in organogenesis: Making the difference. Trends in Genetics, 31(6), 329-335. doi:10.1016/j.tig.2015.02.002.

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© 2015 Elsevier B.V.
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 Creators:
Grote, Phillip1, Author              
Herrmann, Bernhard G.1, Author              
Affiliations:
1Dept. of Developmental Genetics (Head: Bernhard G. Herrmann), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433548              

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Free keywords: lncRNAs; embryo; development; organ; cell lineage
 Abstract: A large proportion of the cellular transcriptome of higher vertebrates consists of non-protein coding transcripts, among them the long noncoding RNAs (lncRNAs). Although lncRNAs are functionally extremely divergent, many ncRNAs have been shown to interact with chromatin modifying complexes and/or with transcriptional regulators. Via such interactions, many lncRNAs are involved in controlling the activity and expression level of target genes, including important regulators of embryonic processes, and thereby fine-tune gene regulatory networks controlling cell fate, lineage balance, and organogenesis. Intriguingly, an increase in organ complexity during evolution parallels a rise in lncRNA abundance. The current data suggest that lncRNAs support the generation of cell diversity and organ complexity during embryogenesis, and thereby have promoted the evolution of more complex organisms.

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Language(s): eng - English
 Dates: 2015-03-022015-06
 Publication Status: Published in print
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.tig.2015.02.002
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Title: Trends in Genetics
  Other : Trends Genet.
Source Genre: Journal
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Publ. Info: Elsevier Current Trends
Pages: - Volume / Issue: 31 (6) Sequence Number: - Start / End Page: 329 - 335 Identifier: ISSN: 0168-9525
CoNE: https://pure.mpg.de/cone/journals/resource/954925485719