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  Scanning and resetting the phase of a pinned spiral wave using periodic far field pulses

Shajahan, T. K., Berg, S., Luther, S., Krinsky, V. I., & Bittihn, P. (2016). Scanning and resetting the phase of a pinned spiral wave using periodic far field pulses. New Journal of Physics, 18(4), 043012. doi:10.1088/1367-2630/18/4/043012.

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Shajahan, T. K.1, Author              
Berg, Sebastian1, Author              
Luther, Stefan1, Author              
Krinsky, Valentin I.1, Author              
Bittihn, Philip1, Author              
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1Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2063288              

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 Abstract: Spiral waves in cardiac tissue can pin to tissue heterogeneities and form stable pinned waves. These waves can be unpinned by electric stimuli applied close to the pinning center during the vulnerable window of the spiral. Using a phase transition curve (PTC), we quantify the response of a pinned wave in a cardiac monolayer to secondary excitations generated electric field pulses. The PTC can be used to construct a one-dimensional map that faithfully predicts the pinned wave’s response to periodic field stimuli. Based on this 1D map, we predict that pacing at a frequency greater than the spiral frequency, over drive pacing, leads to phase locking of the spiral to the stimulus, which hinders unpinning. In contrast, under drive pacing can lead to scanning of the phase window of the spiral, which facilitates unpinning. The predicted mechanisms of phase scanning and phase locking are experimentally tested and confirmed in the same monolayers that were used to obtain the PTC. Our results have the potential to help choose optimal parameters for low energy antifibrillation pacing schemes.

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 Dates: 2016-03-042015-12-152016-03-112016-04-07
 Publication Status: Published in print
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 Identifiers: DOI: 10.1088/1367-2630/18/4/043012
BibTex Citekey: shajahan_scanning_2016
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Title: New Journal of Physics
  Abbreviation : New J. Phys.
Source Genre: Journal
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Publ. Info: Bristol : IOP Publishing
Pages: - Volume / Issue: 18 (4) Sequence Number: - Start / End Page: 043012 Identifier: ISSN: 1367-2630
CoNE: https://pure.mpg.de/cone/journals/resource/954926913666