English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Probing chromatin-modifying enzymes with chemical tools.

Fischle, W., & Schwarzer, D. (2016). Probing chromatin-modifying enzymes with chemical tools. ACS Chemical Biology, 11(3), 689-705. doi:10.1021/acschembio.5b01023.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-323D-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-A8F3-C
Genre: Journal Article

Files

show Files
hide Files
:
2266452.pdf (Publisher version), 3MB
 
File Permalink:
-
Name:
2266452.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Biophysical Chemistry (Karl Friedrich Bonhoeffer Institute), Göttingen; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Fischle, W.1, Author              
Schwarzer, D., Author
Affiliations:
1Research Group of Chromatin Biochemistry, MPI for biophysical chemistry, Max Planck Society, ou_578604              

Content

show
hide
Free keywords: -
 Abstract: Chromatin is the universal template of genetic information in all eukaryotic organisms. Chemical modifications of the DNA-packaging histone proteins and the DNA bases are crucial signaling events in directing the use and readout of eukaryotic genomes. The enzymes that install and remove these chromatin modifications as well as the proteins that bind these marks govern information that goes beyond the sequence of DNA. Therefore, these so-called epigenetic regulators are intensively studied and represent promising drug targets in modern medicine. We summarize and discuss recent advances in the field of chemical biology that have provided chromatin research with sophisticated tools for investigating the composition, activity, and target sites of chromatin modifying enzymes and reader proteins.

Details

show
hide
Language(s): eng - English
 Dates: 2016-02-042016-03-18
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1021/acschembio.5b01023
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: ACS Chemical Biology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 11 (3) Sequence Number: - Start / End Page: 689 - 705 Identifier: -