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  A new population of parvocellular oxytocin neurons controlling magnocellular neuron activity and inflammatory pain processing

Eliava, M., Melchior, M., Knobloch-Bollmann, H. S., Wahis, J., da Gouveia, M. S., Tang, Y., et al. (2016). A new population of parvocellular oxytocin neurons controlling magnocellular neuron activity and inflammatory pain processing. Neuron, 89(6), 1291-1304. doi:10.1016/j.neuron.2016.01.041.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-35AF-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-35B0-8
Genre: Journal Article

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 Creators:
Eliava, Marina, Author
Melchior, Meggane, Author
Knobloch-Bollmann, H. Sophie1, Author              
Wahis, Jérôme, Author
da Gouveia, Miriam Silva, Author
Tang, Yan, Author
Ciobanu, Alexandru Cristian, Author
Rio, Rodrigo Triana del, Author
Roth, Lena C.1, Author              
Althammer, Ferdinand, Author
Chavant, Virginie, Author
Goumon, Yannick, Author
Gruber, Tim1, Author              
Petit-Demoulière, Nathalie, Author
Busnelli, Marta, Author
Chini, Bice, Author
Tan, Linette L., Author
Mitre, Mariela, Author
Froemke, Robert C., Author
Chao, Moses V., Author
Giese, Günter2, Author              Sprengel, Rolf1, Author              Kuner, Rohini, AuthorPoisbeau, Pierrick, AuthorSeeburg, Peter H.1, Author              Stoop, Ron, AuthorCharlet, Alexandre, AuthorGrinevich, Valery1, Author               more..
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              

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 Abstract: Oxytocin (OT) is a neuropeptide elaborated by the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei. Magnocellular OT neurons of these nuclei innervate numerous forebrain regions and release OT into the blood from the posterior pituitary. The PVN also harbors parvocellular OT cells that project to the brainstem and spinal cord, but their function has not been directly assessed. Here, we identified a subset of approximately 30 parvocellular OT neurons, with collateral projections onto magnocellular OT neurons and neurons of deep layers of the spinal cord. Evoked OT release from these OT neurons suppresses nociception and promotes analgesia in an animal model of inflammatory pain. Our findings identify a new population of OT neurons that modulates nociception in a two tier process: (1) directly by release of OT from axons onto sensory spinal cord neurons and inhibiting their activity and (2) indirectly by stimulating OT release from SON neurons into the periphery.

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Language(s): eng - English
 Dates: 2015-08-022015-01-222016-01-212016-03-032016-03-16
 Publication Status: Published in print
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 89 (6) Sequence Number: - Start / End Page: 1291 - 1304 Identifier: ISSN: 0896-6273
CoNE: /journals/resource/954925560565