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  Flexible, AAV-equipped genetic modules for inducible control of gene expression in mammalian brain

Dogbevia, G. K., Roßmanith, M., Sprengel, R., & Hasan, M. T. (2016). Flexible, AAV-equipped genetic modules for inducible control of gene expression in mammalian brain. Molecular Therapy Nucleic Acids, 5: e309, pp. 1-8. doi:10.1038/mtna.2016.23.

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 Creators:
Dogbevia, Godwin K.1, Author           
Roßmanith, Martin1, Author           
Sprengel, Rolf1, Author           
Hasan, Mazahir T.1, Author           
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1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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Free keywords: brain; inducible and reversible gene expression; Tet systems; recombinant adeno-associated virus
 Abstract: Controlling gene expression in mammalian brain is of utmost importance to causally link the role of gene function to cell circuit dynamics under normal conditions and disease states. We have developed recombinant adeno-associated viruses equipped with tetracycline-controlled genetic switches for inducible and reversible control of gene expression in a cell type specific and brain subregion selective manner. Here, we characterize a two-virus approach to efficiently and reliably switch gene expression on and off, repetitively, both in vitro and in vivo. Our recombinant adeno-associated virus (rAAV)-Tet approach is highly flexible and it has great potential for application in basic and biomedical neuroscience research and gene therapy.

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Language(s): eng - English
 Dates: 2015-11-082016-03-012016-04-12
 Publication Status: Published online
 Pages: 8
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 Table of Contents: -
 Rev. Type: Peer
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Title: Molecular Therapy Nucleic Acids
Source Genre: Journal
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Publ. Info: New York, NY : Nature Publ. Group
Pages: - Volume / Issue: 5 Sequence Number: e309 Start / End Page: 1 - 8 Identifier: ISSN: 2162-2531