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  Consequences of Aneuploidy in Cancer: Transcriptome and Beyond

Dürrbaum, M., & Storchova, Z. (2015). Consequences of Aneuploidy in Cancer: Transcriptome and Beyond. Recent Results Cancer Research, 200, 195-224. doi:10.1007/978-3-319-20291-4_9.

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 Creators:
Dürrbaum, Milena1, Author           
Storchova, Zuzana1, Author           
Affiliations:
1Storchova, Zuzana / Maintenance of Genome Stability, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565171              

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Free keywords: Aneuploidy; Cancer; Copy number alterations; Proteome; Transcriptome
 Abstract: Cancer cells differ from normal healthy cells in multiple aspects ranging from altered cellular signaling through metabolic changes to aberrant chromosome content, so called aneuploidy. The large-scale changes in copy numbers of chromosomes or large chromosomal regions due to aneuploidy alter significantly the gene expression, as several hundreds of genes are gained or lost. Comparison of quantitative genome, transcriptome and proteome data enables dissection of the molecular causes that underlie the gene expression changes observed in cancer cells and provides a new perspective on the molecular consequences of aneuploidy. Here, we will map to what degree aneuploidy affects the expression of genes located on the affected chromosomes. We will also address the effects of aneuploidy on global gene expression in cancer cells as well as whether and how it may contribute to the physiology of cancer cells

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Language(s): eng - English
 Dates: 2015
 Publication Status: Issued
 Pages: 29
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1007/978-3-319-20291-4_9
 Degree: -

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Title: Recent Results Cancer Research
Source Genre: Journal
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Publ. Info: Berlin : Springer
Pages: - Volume / Issue: 200 Sequence Number: - Start / End Page: 195 - 224 Identifier: ISSN: 0080-0015