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  A universal mechanism for transport and regulation of CPA sodium proton exchangers

Calinescu, O., & Fendler, K. (2015). A universal mechanism for transport and regulation of CPA sodium proton exchangers. Biological Chemistry, 396(9-10), 1091-1096. doi:10.1515/hsz-2014-0278.

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 Creators:
Calinescu, Octavian1, 2, Author           
Fendler, Klaus1, Author           
Affiliations:
1Department of Biophysical Chemistry, Max Planck Institute of Biophysics, Max Planck Society, ou_2068289              
2Department of Biophysics, Faculty of Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, RO-050474 Bucharest, Romania, ou_persistent22              

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Free keywords: cation/proton antiporter superfamily; Na+/H+ exchangers; NhaA; NhaP1; pH regulation; transport mechanism
 Abstract: Recent studies performed on a series of Na+/H+ exchangers have led us to postulate a general mechanism for Na+/H+ exchange in the monovalent cation/proton antiporter superfamily. This simple mechanism employs a single binding site for which both substrates compete. The developed kinetic model is self-regulatory, ensuring down-regulation of transport activity at extreme pH, and elegantly explains the pH-dependent activity of Na+/H+ exchangers. The mechanism was experimentally verified and shown to describe both electrogenic and electroneutral exchangers. Using a small number of parameters, exchanger activity can be modeled under different conditions, providing insights into the physiological role of Na+/H+ exchangers.

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Language(s): eng - English
 Dates: 2014-11-282015-01-262015-01-282015-09
 Publication Status: Published in print
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1515/hsz-2014-0278
 Degree: -

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Title: Biological Chemistry
  Other : Biological Chemistry Hoppe-Seyler (Berlin)
  Abbreviation : Biol Chem Hoppe Seyler
Source Genre: Journal
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Affiliations:
Publ. Info: Berlin : W. de Gruyter
Pages: - Volume / Issue: 396 (9-10) Sequence Number: - Start / End Page: 1091 - 1096 Identifier: Other: 1437-4315
ISSN: 1431-6730
CoNE: https://pure.mpg.de/cone/journals/resource/954927622123