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  Long-term NR2B expression in the cerebellum alters granule cell development and leads to NR2A down-regulation and motor deficits

Schlett, K., Pieri, I., Metzger, F., Marchetti, L., Steigerwald, F., Dere, E., et al. (2004). Long-term NR2B expression in the cerebellum alters granule cell development and leads to NR2A down-regulation and motor deficits. Cellular and Molecular Neurobiology, 27(3), 215-226. doi:10.1016/j.mcn.2004.05.008.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-39BA-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-39BB-0
Genre: Journal Article
Alternative Title : Long-term NR2B expression in the cerebellum alters granule cell development and leads to NR2A down-regulation and motor deficits

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 Creators:
Schlett, Katalin, Author
Pieri, Isabelle, Author
Metzger, Friedrich, Author
Marchetti, Lara, Author
Steigerwald, Frank1, Author              
Dere, Ekrem, Author
Kirilly, Daniel, Author
Tarnok, Krisztian, Author
Barabas, Brigitta, Author
Varga, Agnes Kis, Author
Gerspach, Jeannette, Author
Huston, Joseph P., Author
Pfizenmaier, Klaus, Author
Köhr, Georg1, Author              
Eisel, Ulrich L. M., Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: N−methyl−D−aspartate receptor (NMDAR) composition in granule cells changes characteristically during cerebellar development. To analyze the importance of NR2B replacement by NR2C and NR2A subunits until the end of the first month of age, we generated mice with lasting NR2B expression but deficiency for NR2C (NR2C−2B mice). Mutant phenotype was different from NR2C knock−out mice as loss of granule cells and morphological changes in NR2C/2B cerebellar architecture were already evident from the second postnatal week. Increased NR2B subunit levels led also to a gradual down−regulation of cerebellar NR2A levels, preceding the development of motor impairment in adult animals. Therefore, cerebellar NR2A is important for proper motor coordination and cannot be replaced by long−term expression of NR2B. Consequently, the physiological exchange of NMDA receptor subunits during cerebellar granule cell maturation is important for accurate postnatal development and function

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Language(s): eng - English
 Dates: 2004-04-302004-03-122004-05-262004-09-182004-11-01
 Publication Status: Published in print
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: Cellular and Molecular Neurobiology
  Other : Cell. Mol. Neurobiol.
Source Genre: Journal
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Publ. Info: New York, NY : Kluwer Academic/Plenum Publishers
Pages: - Volume / Issue: 27 (3) Sequence Number: - Start / End Page: 215 - 226 Identifier: ISSN: 0272-4340
CoNE: https://pure.mpg.de/cone/journals/resource/954925503218