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Abstract:
In this talk, we will see through the large voxel acquired from conventional fMRI method to decipher the contribution from distinct vascular components to fMRI signal. The individual arterioles and venules penetrating cortices were directly mapped based on the blood in-flow effect and fast T2* decay of the de-oxygenated blood. Distinct blood-oxygen level dependent (BOLD) and cerebral blood volume (CBV) fMRI signal was detected on individual venules and arterioles with 100ms temporal resolution. This fast sampling rate allows us to identify the activity-evoked hemodynamic signal propagation through cerebrovasculature in the deep cortical layer of the somatosensory cortex. In addition, I will show you our recent progress on light-driven fMRI with optogenetics and fiber-optic mediated calcium recording methods through GCaMP6. We are aiming to implement fiber-optic mediated optical methods to makes fMRI more suitable for mechanistic studies on neurovascular coupling. At last, I will present our recently developed MRI-guided robotic arms to target deep brain nuclei in rats.
