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  Gd3+-Based Magnetic Resonance Imaging Contrast Agent Responsive to Zn2+

Regueiro-Figueroa, M., Gündüz, S., Patinec, V., Logothetis, N., Esteban-Gómez, D., Tripier, R., et al. (2015). Gd3+-Based Magnetic Resonance Imaging Contrast Agent Responsive to Zn2+. Inorganic Chemistry, 54(21), 10342-10350. doi:10.1021/acs.inorgchem.5b01719.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-43B1-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-62E0-4
Genre: Journal Article

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Regueiro-Figueroa, M, Author
Gündüz, S1, 2, Author              
Patinec, V, Author
Logothetis, NK1, 3, Author              
Esteban-Gómez, D, Author
Tripier, R, Author
Angelovski, G1, 2, Author              
Platas-Iglesias, C, Author
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528691              
3Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

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 Abstract: We report the heteroditopic ligand H5L, which contains a DO3A unit for Gd3+ complexation connected to an NO2A moiety through a N-propylacetamide linker. The synthesis of the ligand followed a convergent route that involved the preparation of 1,4-bis(tert-butoxycarbonylmethyl)-1,4,7-triazacyclononane following the orthoamide strategy. The luminescence lifetimes of the Tb(5D4) excited state measured for the TbL complex point to the absence of coordinated water molecules. Density functional theory calculations and 1H NMR studies indicate that the EuL complex presents a square antiprismatic coordination in aqueous solution, where eight coordination is provided by the seven donor atoms of the DO3A unit and the amide oxygen atom of the N-propylacetamide linker. Addition of Zn2+ to aqueous solutions of the TbL complex provokes a decrease of the emission intensity as the emission lifetime becomes shorter, which is a consequence of the coordination of a water molecule to the Tb3+ ion upon Zn2+ binding to the NO2A moiety. The relaxivity of the GdL complex recorded at 7 T (25 °C) increases by almost 150 in the presence of 1 equiv of Zn2+, while Ca2+ and Mg2+ induced very small relaxivity changes. In vitro magnetic resonance imaging experiments confirmed the ability of GdL to provide response to the presence of Zn2+.

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 Dates: 2015-11
 Publication Status: Published in print
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 Identifiers: DOI: 10.1021/acs.inorgchem.5b01719
BibTex Citekey: RegueiroFigueroaGPLETAP2015
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Title: Inorganic Chemistry
Source Genre: Journal
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Pages: - Volume / Issue: 54 (21) Sequence Number: - Start / End Page: 10342 - 10350 Identifier: -