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  Robustness of sensory-evoked excitation is increased by inhibitory inputs to distal apical tuft dendrites

Egger, R., Schmitt, A., Wallace, D., Sakmann, B., Oberlaender, M., & Kerr, J. (2015). Robustness of sensory-evoked excitation is increased by inhibitory inputs to distal apical tuft dendrites. Proceedings of the National Academy of Sciences of the United States of America, 112(45), 14072-14077. doi:10.1073/pnas.1518773112.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-43B9-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-B4B9-4
Genre: Journal Article

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 Creators:
Egger, R1, Author              
Schmitt, AC2, Author              
Wallace, DJ2, Author              
Sakmann, B, Author
Oberlaender, M1, Author              
Kerr, JND2, Author              
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Research Group Neural Population Imaging, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497807              

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 Abstract: Cortical inhibitory interneurons (INs) are subdivided into a variety of morphologically and functionally specialized cell types. How the respective specific properties translate into mechanisms that regulate sensory-evoked responses of pyramidal neurons (PNs) remains unknown. Here, we investigated how INs located in cortical layer 1 (L1) of rat barrel cortex affect whisker-evoked responses of L2 PNs. To do so we combined in vivo electrophysiology and morphological reconstructions with computational modeling. We show that whisker-evoked membrane depolarization in L2 PNs arises from highly specialized spatiotemporal synaptic input patterns. Temporally L1 INs and L2–5 PNs provide near synchronous synaptic input. Spatially synaptic contacts from L1 INs target distal apical tuft dendrites, whereas PNs primarily innervate basal and proximal apical dendrites. Simulations of such constrained synaptic input patterns predicted that inactivation of L1 INs increases trial-to-trial variability of whisker-evoked responses in L2 PNs. The in silico predictions were confirmed in vivo by L1-specific pharmacological manipulations. We present a mechanism—consistent with the theory of distal dendritic shunting—that can regulate the robustness of sensory-evoked responses in PNs without affecting response amplitude or latency.

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 Dates: 2015-11
 Publication Status: Published in print
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 Identifiers: DOI: 10.1073/pnas.1518773112
BibTex Citekey: EggerSWSOK2015
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Title: Proceedings of the National Academy of Sciences of the United States of America
Source Genre: Journal
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Pages: - Volume / Issue: 112 (45) Sequence Number: - Start / End Page: 14072 - 14077 Identifier: -