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  Triggers of entorhinal grid cell and hippocampal place cell remapping in humans

Stangl, M., Meilinger, T., Pape, A.-A., Schultz, J., Bülthoff, H., & Wolbers, T. (2015). Triggers of entorhinal grid cell and hippocampal place cell remapping in humans. Poster presented at 45th Annual Meeting of the Society for Neuroscience (Neuroscience 2015), Chicago, IL, USA.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-43EB-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-C791-5
Genre: Poster

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http://www.sfn.org/am2015/ (Publisher version)
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 Creators:
Stangl, M, Author
Meilinger, T1, 2, Author              
Pape, A-A1, 2, Author              
Schultz, J1, 2, Author              
Bülthoff, HH1, 2, Author              
Wolbers, T, Author
Affiliations:
1Department Human Perception, Cognition and Action, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497797              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Navigating the environment requires the integration of distance, direction, and place information, which critically depends on hippocampal place and entorhinal grid cells. Studies in rodents have shown, however, that substantial changes in the environment’s surroundings can trigger a change in the set of active place cells, accompanied by a rotation of the grid cell firing pattern (Fyhn et al., 2007) - a phenomenon commonly referred to as global remapping. In the present study, we investigated whether human grid and place cells show a similar remapping behavior in response to environmental changes and whether different episodes in the same environment might cause remapping as well. In two experiments, participants underwent 3T fMRI scanning while they navigated a virtual environment, comprising two different rooms in which objects were placed in random locations. Participants explored the first room and learned these object-location conjunctions (learning-phase), after which the objects disappeared and participants were asked to navigate repeatedly to the different object locations (test-phase). This procedure (i.e. a learning- and test-phase within a room) was repeated several times, separated by different events, such as leaving and re-entering the same room, or moving to the second, different room. Indicators of grid cell firing were derived from the BOLD activation while participants moved within the virtual environment, whereas indicators of place cell firing were derived from the activation patterns while participants were standing at particular object locations. We compared these indicators between the different rooms and events to investigate how these manipulations influence remapping. Overall, our findings demonstrate entorhinal grid cell and hippocampal place cell remapping in humans. Furthermore, our results suggest that beside environmental changes, also other events (e.g., re-entering the same environment) might evoke remapping. We conclude that, in humans, remapping is not only environment-based but also event-based and might serve as a neural mechanism to create distinct memory traces for episodic memory formation.

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 Dates: 2015-10-19
 Publication Status: Published in print
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 Identifiers: BibTex Citekey: StanglMPSBW2015
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Title: 45th Annual Meeting of the Society for Neuroscience (Neuroscience 2015)
Place of Event: Chicago, IL, USA
Start-/End Date: 2015-10-17 - 2015-10-22

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Title: 45th Annual Meeting of the Society for Neuroscience (Neuroscience 2015)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 437.04 Start / End Page: - Identifier: -