English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Atomoxetine accelerates attentional set shifting without affecting learning rate in the rat

Totah, N., Logothetis, N., & Eschenko, O. (2015). Atomoxetine accelerates attentional set shifting without affecting learning rate in the rat. Psychopharmacology, 232(20), 3697-3707. doi:10.1007/s00213-015-4028-5.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-440E-E Version Permalink: http://hdl.handle.net/21.11116/0000-0000-B4FC-9
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Totah, NK1, Author              
Logothetis, NK1, Author              
Eschenko, O1, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

Content

show
hide
Free keywords: -
 Abstract: Rationale Shifting to a new rule is a form of behavioral flexibility that is impaired in numerous psychiatric and neurological illnesses. Animal studies have revealed that this form of flexibility depends upon norepinephrine (NE) neurotransmission. Atomoxetine, a NE reuptake inhibitor, improves performance of humans in set shifting tasks. Objective Our objective was to validate its effects in a rodent set shifting task. Methods We tested the drug effect using an operant task that required a shift from a visual cue-guided behavior to a novel location-guided rule. Results A 1.0-mg/kg dose significantly accelerated rule shifting without affecting learning strategies, such as win-stay or lose-shift. Fitting behavioral performance with a learning function provided a measure of learning rate. Conclusion This novel analysis revealed that atomoxetine accelerated shifting to the new rule without affecting learning rate.

Details

show
hide
Language(s):
 Dates: 2015-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1007/s00213-015-4028-5
BibTex Citekey: TotahLE2015
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Psychopharmacology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 232 (20) Sequence Number: - Start / End Page: 3697 - 3707 Identifier: -