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  Simultaneous epidural functional near-infrared spectroscopy and cortical electrophysiology as a tool for studying local neurovascular coupling in primates

Zaidi, A., Munk, M., Schmidt, A., Risueno-Segovia, C., Bernard, R., Fetz, E., et al. (2015). Simultaneous epidural functional near-infrared spectroscopy and cortical electrophysiology as a tool for studying local neurovascular coupling in primates. NeuroImage, 120, 394-399. doi:10.1016/j.neuroimage.2015.07.019.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-4418-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-B5FF-5
Genre: Journal Article

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 Creators:
Zaidi, AD1, Author              
Munk, MHJ1, Author              
Schmidt, A1, Author              
Risueno-Segovia, C1, Author              
Bernard, R1, Author              
Fetz, E, Author
Logothetis, NK1, Author              
Bierbaumer, N, Author
Sitaram, R1, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

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 Abstract: Simultaneous measurements of intra-cortical electrophysiology and hemodynamic signals in primates are essential for relating human neuroimaging studies with intra-cortical electrophysiology in monkeys. Previously, technically challenging and resourcefully demanding techniques such as fMRI and intrinsic-signal optical imaging have been used for such studies. Functional near-infrared spectroscopy is a relatively less cumbersome neuroimaging method that uses near-infrared light to detect small changes in concentrations of oxy-hemoglobin (HbO), deoxy-hemoglobin (HbR) and total hemoglobin (HbT) in a volume of tissue with high specificity and temporal resolution. fNIRS is thus a good candidate for hemodynamic measurements in primates to acquire local hemodynamic signals during electrophysiological recordings. To test the feasibility of using epidural fNIRS with concomitant extracellular electrophysiology, we recorded neuronal and hemodynamic activity from the primary visual cortex of two anesthetized monkeys during visual stimulation. We recorded fNIRS epidurally, using one emitter and two detectors. We performed simultaneous cortical electrophysiology using tetrodes placed between the fNIRS sensors. We observed robust and reliable responses to the visual stimulation in both [HbO] and [HbR] signals, and quantified the signal-to-noise ratio of the epidurally measured signals. We also observed a positive correlation between stimulus-induced modulation of [HbO] and [HbR] signals and strength of neural modulation. Briefly, our results show that epidural fNIRS detects single-trial responses to visual stimuli on a trial-by-trial basis, and when coupled with cortical electrophysiology, is a promising tool for studying local hemodynamic signals and neurovascular coupling.

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 Dates: 2015-10
 Publication Status: Published in print
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 Identifiers: DOI: 10.1016/j.neuroimage.2015.07.019
BibTex Citekey: ZaidiMSRBFLBS2015
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Title: NeuroImage
Source Genre: Journal
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Pages: - Volume / Issue: 120 Sequence Number: - Start / End Page: 394 - 399 Identifier: -