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  Spike Sorting of Synchronous Spikes from Local Neuron Ensembles

Franke, F., Pröpper, R., Alle, H., Meier, P., Geiger, J., Obermayer, K., et al. (2015). Spike Sorting of Synchronous Spikes from Local Neuron Ensembles. Journal of Neurophysiology, 114(4), 2535-2549. doi:10.1152/jn.00993.2014.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-441A-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-B604-E
Genre: Journal Article

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Franke, F1, Author              
Pröpper, R, Author
Alle, H, Author
Meier, P, Author
Geiger, JRP, Author
Obermayer, K, Author
Munk, MHJ1, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

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 Abstract: Synchronous spike discharge of cortical neurons is thought to be a fingerprint of neuronal cooperativity. Because neighboring neurons are more densely connected to one another than neurons that are located further apart, near-synchronous spike discharge can be expected to be prevalent and it might provide an important basis for cortical computations. Using microelectrodes to record local groups of neurons does not allow for the reliable separation of synchronous spikes from different cells, because available spike sorting algorithms cannot correctly resolve the temporally overlapping waveforms. We show that high spike sorting performance of in vivo recordings, including overlapping spikes, can be achieved using a recently developed filter-based template matching procedure. Using tetrodes with a 3-dimensional structure, we demonstrate with simulated data and ground truth in vitro data, obtained by dual intracellular recording of two neurons located next to a tetrode, that the spike sorting of synchronous spikes can be as successful as the spike sorting of non-overlapping spikes, and that the spatial information provided by multielectrodes greatly reduces the error rates. We apply the method to tetrode recordings from the prefrontal cortex of behaving primates and we show that overlapping spikes can be identified and assigned to individual neurons to study synchronous activity in local groups of neurons.

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 Dates: 2015-10
 Publication Status: Published in print
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 Identifiers: DOI: 10.1152/jn.00993.2014
BibTex Citekey: FrankePAMGOM2015
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Title: Journal of Neurophysiology
Source Genre: Journal
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Pages: - Volume / Issue: 114 (4) Sequence Number: - Start / End Page: 2535 - 2549 Identifier: -