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  Fast and efficient free induction decay proton MRSI in the human brain at 9.4 T

Chadzynski, G., Scheffler, K., Bause, J., Shajan, G., Pohmann, R., & Ehses, P. (2015). Fast and efficient free induction decay proton MRSI in the human brain at 9.4 T. Magnetic Resonance Materials in Physics, Biology and Medicine, 28(Supplement 1), S298-S299.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-4453-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-C872-E
Genre: Meeting Abstract

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 Creators:
Chadzynski, GL1, Author              
Scheffler, K1, Author              
Bause, J1, Author              
Shajan, G1, Author              
Pohmann, R1, 2, Author              
Ehses, P1, Author              
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Dept. Empirical Inference, Max Planck Institute for Intelligent Systems, Max Planck Society, ou_1497647              

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 Abstract: Purpose/Introduction: Free induction decay (FID) based MRSI has been shown to be highly promising at ultra-high magnetic field [1, 2]. It avoids in-plane chemical shift displacement and allows short echo time. However, the necessity to use fat and water saturation results in an excessive amount of time needed for signal preparation. Thus, our aim was to improve the time efficiency of the MRSI-FID sequence to obtain spectra with high spatial resolution within reasonable time. Subjects and Methods: Spectra were acquired at a 9.4 T whole body scanner (Siemens, Erlangen,Germany) from the superior part of the brain of a healthy volunteer (male, 34 years old) with approval by the local ethics committee. A 16 channel transmit, 31 channel receive coil [3] was used for signal transmission/reception. B0 field inhomogeneities were minimized by second order image based shimming. The sequence was preceded by a non-localized fat saturation gauss pulse, allowing reduction of the fat contaminations by approximately 40 . The flip angles of three water saturation pulseswere optimized for aT1 range of 800–2800 ms and B1 + inhomogeneities of±50 using aBloch simulation. Exchanging the sinc excitation pulse with an asymmetric pulse shortened the acquisition delay (TE) to 1 ms. The optimized sequence is presented in Fig. 1. The following parameters were used for in vivo data acquisition: TR = 150 ms, TE = 1 ms, spectral bandwidth = 5000 Hz, acquisition duration = 108 ms, nominal voxel size 6 9 6910 mm (32 9 32 voxels), density weighting with 2 averages and acquisition timeof 2 min 19 s. Coil combinationwas performed using the adaptive combine method [4]. Fig. 1 Time diagram of the optimized MRSI-FID sequence. Abbreviations used: fat saturation pulse, FatSat; water suppression pulse, WET; excitation pulse, Excit Results: Spectra obtained with the proposed sequence are of reasonable quality (Fig. 2). Although the fat signal is still present, it does not hamper the spectral range of interest (between 4.3 and 1.8 ppm), even in the voxels which are close to scalp (black and green). Differences in the intensity of the presented spectra could be caused by B1-field. Results: Spectra obtained with the proposed sequence are of reasonable quality (Fig. 2). Although the fat signal is still present, it does not hamper the spectral range of interest (between 4.3 and 1.8 ppm), even in the voxels which are close to scalp (black and green). Differences in the intensity of the presented spectra could be caused by B1-field inhomogeneities. Discussion/Conclusion: The presented sequence allows fast and efficient acquisition of MRSI spectra. It allows to acquire a 32 9 32 spectral matrix within less than 2.5 min. Further acceleration could be done using parallel imaging techniques. Relatively large fat residuals indicate the necessity of further optimization of the fat saturation. Additional effort is also needed for reducing the influence of B0 and B1 +-variations on the measured spectra.

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 Dates: 2015-10
 Publication Status: Published in print
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 Identifiers: DOI: 10.1007/s10334-015-0489-0
BibTex Citekey: ChadzynskiSBSPE2015
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Title: 32nd Annual Scientific Meeting ESMRMB 2015
Place of Event: Edinburgh, UK
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Title: Magnetic Resonance Materials in Physics, Biology and Medicine
Source Genre: Journal
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Pages: - Volume / Issue: 28 (Supplement 1) Sequence Number: - Start / End Page: S298 - S299 Identifier: -