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  Necessity of tissue volume composition correction for internal referencing

Zoelch, N., Hock, A., Scheidegger, M., Hulka, L., Quednow, B., & Henning, A. (2015). Necessity of tissue volume composition correction for internal referencing. Poster presented at 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015), Toronto, Canada.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002A-45EF-C Version Permalink: https://hdl.handle.net/21.11116/0000-0006-9B7E-F
Genre: Poster

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http://www.ismrm.org/15/program_files/WedTP03.htm (Publisher version)
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 Creators:
Zoelch, N, Author
Hock, A, Author
Scheidegger, M, Author
Hulka, L, Author
Quednow, B, Author
Henning, A1, 2, Author           
Affiliations:
1Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528692              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: The goal of this work was to investigate absolute quantification of brain metabolites in heterogeneous voxels using internal references. To obtain reliable concentrations in heterogeneous voxels, it is necessary to include corrections for the different concentrations as well as different relaxation properties in grey matter, white matter and cerebrospinal fluid of the reference compound. Absolute concentrations were determined in 18 healthy volunteers either by using the internal water as reference or internal creatine and applying the commonly used corrections. A good agreement between the mean concentrations obtained with both reference standards could be only observed when the commonly used corrections are applied. However the correlation between these concentrations compared to correlation of the simple peak area ratios was decreased.

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 Dates: 2015-06
 Publication Status: Issued
 Pages: -
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 Identifiers: BibTex Citekey: ZoelchHSHQH2015
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Title: 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015)
Place of Event: Toronto, Canada
Start-/End Date: 2015-05-30 - 2015-06-05

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Title: 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 1977 Start / End Page: - Identifier: -