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  Sensing the high magnetic field: Fusion of otoliths in zebrafish larvae entails a hint

Pais Roldán, P., Singh, A., Merkle, H., Schulz, H., & Yu, X. (2015). Sensing the high magnetic field: Fusion of otoliths in zebrafish larvae entails a hint. In 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015).

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002A-45F9-3 Version Permalink: https://hdl.handle.net/21.11116/0000-0000-FD8F-3
Genre: Meeting Abstract

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http://www.ismrm.org/15/program_files/WedSci13.htm (Publisher version)
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 Creators:
Pais Roldán, P1, 2, Author           
Singh, A, Author
Merkle, H3, Author           
Schulz, H3, Author           
Yu, X1, 2, Author           
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528695              
3Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497796              

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 Abstract: Here we described the impact of the high magnetic field (MF) on zebrafish larvae aiming to identify potential biological MR sensors. 14T-MF exposures longer than 2 hours in zebrafish larvae led to fusion of 2 otoliths (CaCO3 crystals in the inner ear responsible for balance and hearing) and a subsequent aberrant balance behavior, a phenotype already described in genetic mutants. Identification of the cellular and molecular mechanisms underlying this MF-induced otolith-fusion may be tackled with a zebrafish mutagenesis approach and might contribute in an efficient way to search for MR sensors in biological models.

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 Dates: 2015-06-03
 Publication Status: Issued
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 Identifiers: BibTex Citekey: PaisRoldanSMSY2015
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Title: 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015)
Place of Event: Toronto, Canada
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Title: 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 0695 Start / End Page: - Identifier: -