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  In vivo proton magnetic resonance spectroscopic imaging of the healthy human brain at 9.4 T: initial experience

Chadzynski, G., Pohmann, R., Shajan, G., Kolb, R., Bisdas, S., Klose, U., et al. (2015). In vivo proton magnetic resonance spectroscopic imaging of the healthy human brain at 9.4 T: initial experience. Magnetic Resonance Materials in Physics, Biology and Medicine, 28(3), 239-249. doi:10.1007/s10334-014-0460-5.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-463F-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-9B67-8
Genre: Journal Article

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Chadzynski, GL1, 2, Author              
Pohmann, R1, 2, Author              
Shajan, G1, 2, Author              
Kolb, R, Author
Bisdas, S, Author
Klose, U, Author
Scheffler, K1, 2, Author              
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Object In this study, the feasibility of in vivo proton magnetic resonance spectroscopic imaging (1H MRSI) of the healthy human brain at a field strength of 9.4 T, using conventional acquisition techniques, is examined and the initial experience is summarized. Materials and methods MRSI measurements were performed on a 9.4 T MR scanner (Siemens, Erlangen, Germany) equipped with head-only gradient insert (AC84, Siemens) and custom-developed, 8-channel transmit/24-channel receive, and 16-channel transmit/31-channel receive coils. Spectra were acquired from the superior part of the human brain with a modified STEAM sequence. Spectral quantification was done with LCModel software. Results Reasonable quality and signal-to-noise ratio of the acquired spectra allowed reliable quantification of 12 metabolites (Cramer-Rao lower bounds < 20 ), some of which may be difficult to quantify at field strengths below 7 T due to overlapping resonances or low concentrations. Conclusion While further developments are necessary to minimize chemical shift displacement and homogeneity of the transmit field, it is demonstrated that in vivo 1H MRSI at a field strength of 9.4 T is possible. However, further studies applying up-to-date techniques to overcome high-field specific problems are needed in order to assess the potential gain in sensitivity that may be offered by MRSI at 9.4 T.

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 Dates: 2015-06
 Publication Status: Published in print
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 Identifiers: DOI: 10.1007/s10334-014-0460-5
BibTex Citekey: ChadzynskiPSKBKS2014
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Title: Magnetic Resonance Materials in Physics, Biology and Medicine
Source Genre: Journal
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Publ. Info: Amsterdam : No longer published by Elsevier
Pages: - Volume / Issue: 28 (3) Sequence Number: - Start / End Page: 239 - 249 Identifier: ISSN: 0968-5243
CoNE: https://pure.mpg.de/cone/journals/resource/954926245532