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  Different forms of effective connectivity in primate frontotemporal pathways

Petkov, C., Kikuchi, Y., Milne, A., Mishkin, M., Rauschecker, J., & Logothetis, N. (2015). Different forms of effective connectivity in primate frontotemporal pathways. Nature Communications, 6: 6000, pp. 1-12. doi:10.1038/ncomms7000.

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Petkov, CI1, 2, Author           
Kikuchi, Y, Author
Milne, AE, Author
Mishkin, M, Author
Rauschecker, JP, Author           
Logothetis, NK1, 2, Author           
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: It is generally held that non-primary sensory regions of the brain have a strong impact on frontal cortex. However, the effective connectivity of pathways to frontal cortex is poorly understood. Here we microstimulate sites in the superior temporal and ventral frontal cortex of monkeys and use functional magnetic resonance imaging to evaluate the functional activity resulting from the stimulation of interconnected regions. Surprisingly, we find that, although certain earlier stages of auditory cortical processing can strongly activate frontal cortex, downstream auditory regions, such as voice-sensitive cortex, appear to functionally engage primarily an ipsilateral temporal lobe network. Stimulating other sites within this activated temporal lobe network shows strong activation of frontal cortex. The results indicate that the relative stage of sensory processing does not predict the level of functional access to the frontal lobes. Rather, certain brain regions engage local networks, only parts of which have a strong functional impact on frontal cortex.

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 Dates: 2015-01
 Publication Status: Issued
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 Identifiers: DOI: 10.1038/ncomms7000
BibTex Citekey: PetkovKMMRL2015
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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 6 Sequence Number: 6000 Start / End Page: 1 - 12 Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723