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  A virophage at the origin of large DNA transposons

Fischer, M. G., & Suttle, C. A. (2011). A virophage at the origin of large DNA transposons. Science, 332(6026), 231-234. doi:10.1126/science.1199412.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-4938-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-4939-4
Genre: Journal Article

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Science_332_2011_231.pdf (Any fulltext), 778KB
 
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 Creators:
Fischer, Matthias G.1, Author              
Suttle, Curtis A., Author
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1Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society, ou_1497700              

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 Abstract: DNA transposons are mobile genetic elements that have shaped the genomes of eukaryotes for millions of years, yet their origins remain obscure. We discovered a virophage that, on the basis of genetic homology, likely represents an evolutionary link between double-stranded DNA viruses and Maverick/Polinton eukaryotic DNA transposons. The Mavirus virophage parasitizes the giant Cafeteria roenbergensis virus and encodes 20 predicted proteins, including a retroviral integrase and a protein-primed DNA polymerase B. On the basis of our data, we conclude that Maverick/Polinton transposons may have originated from ancient relatives of Mavirus, and thereby influenced the evolution of eukaryotic genomes, although we cannot rule out alternative evolutionary scenarios.

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Language(s): eng - English
 Dates: 2011-03-032011-03-032011-04-08
 Publication Status: Published in print
 Pages: 5
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 Table of Contents: -
 Rev. Type: Peer
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Title: Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 332 (6026) Sequence Number: - Start / End Page: 231 - 234 Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1