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  Towards understanding the anisotropy of magnetization transfer parameters in human white matter

Pampel, A., Müller, D., Marschner, H., Anwander, A., & Möller, H. E. (2014). Towards understanding the anisotropy of magnetization transfer parameters in human white matter. In Proceedings of the 22nd Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM).

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-4B6B-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-D227-5
Genre: Meeting Abstract

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http://www.ismrm.org/14/program_files/FD01.htm (Table of contents)
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 Creators:
Pampel, André1, Author              
Müller, Dirk1, Author              
Marschner, Henrik1, Author              
Anwander, Alfred2, Author              
Möller, Harald E.1, Author              
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              

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 Abstract: We examine the apparent dependence of qMT parameters, in particular those of the T2 relaxation time of bound protons, on the white matter fiber orientation. It is found that those dependency results from parameter fitting using the Super-Lorentzian lineshape, which renders orientational dependency on other qMT parameters. A novel RF absorption lineshape of the bound pool considering the liquid-crystalline character of the myelin sheath is derived that explains this dependence. Data simulated using this lineshape were analyzed by parameter fitting. A remarkable agreement was found in the obtained parameters compared to those found in WM regions with fractional anisotropy FA>0.7.

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Language(s): eng - English
 Dates: 2014-05-132014-05-132014-05-13
 Publication Status: Published in print
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Title: Proceedings of the 22nd Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM)
Source Genre: Proceedings
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