Pathological glutamatergic neurotransmission in Gilles de la Tourette Syndrome

Kanaan, Ahmad S.; Gerasch, Sarah; García-García, Isabel; Lampe, Leonie; Pampel, André; Anwander, Alfred; Near, Jamie; Müller-Vahl, Kirsten; Möller, Harald E.

Pathological glutamatergic neurotransmission in Gilles de la Tourette Syndrome

Kanaan, A. S., Gerasch, S., García-García, I., Lampe, L., Pampel, A., Anwander, A., Near, J., Müller-Vahl, K., & Möller, H. E. (2016). Pathological glutamatergic neurotransmission in Gilles de la Tourette Syndrome. Poster presented at 24th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM), Singapore.

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アイテムのパーマリンク: https://hdl.handle.net/11858/00-001M-0000-002A-4AA4-0 版のパーマリンク: https://hdl.handle.net/21.11116/0000-0004-F402-6

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Kanaan, Ahmad S.^{1, 2}, 著者
Gerasch, Sarah², 著者
García-García, Isabel³, 著者
Lampe, Leonie³, 著者
Pampel, André¹, 著者
Anwander, Alfred⁴, 著者
Near, Jamie⁵, 著者
Müller-Vahl, Kirsten ², 著者
Möller, Harald E.¹, 著者

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1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558
2Department of Psychiatry, Hannover Medical School, Germany, ou_persistent22
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549
4Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551
5Douglas Mental Health University Institute and Department of Psychiatry, Mcgill University, Montreal, QC, Canada, ou_persistent22

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要旨: We hypothesized that glutamatergic signalling is related to pathophysiology of Gilles de la Tourette syndrome (GTS) and investigated glutamatergic metabolism within cortico-striatal regions using 1H-MRS at baseline and during treatment. Absolute metabolite concentrations were calculated with the consideration of voxel compartmentation following frequency and phase drift correction in the time domain. GTS patients exhibited reductions in striatal and thalamic [Glx], which were normalized with treatment and were correlated with clinical severity parameters. Our results implicate glutamatergic metabolism in GTS pathophysiology and indicate a possibly dysfunctional astrocytic-neuronal coupling system, which would have profound effects on the dopaminergic modulation of cortico-striatal input.

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言語: eng - English

日付: 作成: 2016-05-07

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