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  Vesicle origami and the influence of cholesterol on lipid packing

Tanasescu, R., Lanz, M. A., Mueller, D., Tassler, S., Ishikawa, T., Reiter, R., et al. (2016). Vesicle origami and the influence of cholesterol on lipid packing. Langmuir, 32(19), 4896-4903. doi:10.1021/acs.langmuir.6b01143.

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Tanasescu, Radu, Author
Lanz, Martin A., Author
Mueller, Dennis, Author
Tassler, Stephanie1, Author           
Ishikawa, Takashi, Author
Reiter, Renate, Author
Brezesinski, Gerald1, Author           
Zumbuehl, Andreas, Author
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1Gerald Brezesinski, Kolloidchemie, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863500              

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 Abstract: The artificial phospholipid Pad-PC-Pad was analyzed in 2D (monolayers at the air/water interface) and 3D (aqueous lipid dispersions) systems. In the gel phase, the two leaflets of a Pad-PC-Pad bilayer interdigitate completely and the the hydrophobic bilayer region has a thickness comparable to the length of a single phospholipid acyl chain. This leads to a stiff membrane with no spontaneous curvature. Forced into a vesicular structure, Pad-PC-Pad shows a faceted geometry and in its extreme form, tetrahedral vesicles were found as predicted a decade ago. Above the main-transition temperature, a non-interdigitated Lα phase with fluid chains has been observed. The addition of cholesterol leads to a slight decrease of the main-transition temperature and a gradual decrease of the transition enthalpy until the transition vanishes at 40 mol% cholesterol in the mixture. Additionally, cholesterol pulls the chains apart and a non-interdigitated gel phase is observed. In monolayers, cholesterol has an ordering effect on liquid-expanded phases and disorders condensed phases. The wavenumbers of the methylene stretching vibration indicate the formation of a liquid-ordered raft phase in mixtures with 40 mol% cholesterol.

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 Dates: 2016-04-252016
 Publication Status: Published in print
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 Identifiers: DOI: 10.1021/acs.langmuir.6b01143
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Title: Langmuir
Source Genre: Journal
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Publ. Info: Columbus, OH : American Chemical Society
Pages: - Volume / Issue: 32 (19) Sequence Number: - Start / End Page: 4896 - 4903 Identifier: ISSN: 0743-7463