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  Translational GTPases.

Maracci, C., & Rodnina, M. V. (2016). Translational GTPases. Biopolymers, 105(8), 463-475. doi:10.1002/bip.22832.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-515D-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-E2A8-6
Genre: Journal Article

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 Creators:
Maracci, C.1, Author              
Rodnina, M. V.1, Author              
Affiliations:
1Department of Physical Biochemistry, MPI for Biophysical Chemistry, Max Planck Society, ou_578598              

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Free keywords: Ribosome; Translation; EF-Tu; tRNA; Decoding; GTP hydrolysis
 Abstract: Translational GTPases (trGTPases) play key roles in facilitating protein synthesis on the ribosome. Despite the high degree of evolutionary conservation in the sequences of their GTP-binding domains, the rates of GTP hydrolysis and nucleotide exchange vary broadly between different trGTPases. EF-Tu, one of the best-characterized model G proteins, evolved an exceptionally rapid and tightly regulated GTPase activity, which ensures rapid and accurate incorporation of amino acids into the nascent chain. Other trGTPases instead use the energy of GTP hydrolysis to promote movement or to ensure the forward commitment of translation reactions. Recent data suggest the GTPase mechanism of EF-Tu and provide an insight in the catalysis of GTP hydrolysis by its unusual activator, the ribosome. Here we summarize these advances in understanding the functional cycle and the regulation of trGTPases, stimulated by the elucidation of their structures on the ribosome and the progress in dissecting the reaction mechanism of GTPases

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Language(s): eng - English
 Dates: 2016-03-122016-08
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/bip.22832
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Title: Biopolymers
Source Genre: Journal
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Pages: - Volume / Issue: 105 (8) Sequence Number: - Start / End Page: 463 - 475 Identifier: -