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  Basal ganglia and cerebellar interconnectivity within the human thalamus

Pelzer, E. A., Melzer, C., Timmermann, L., von Cramon, D. Y., & Tittgemeyer, M. (2017). Basal ganglia and cerebellar interconnectivity within the human thalamus. Brain Structure & Function, 222(1), 381-392. doi:10.1007/s00429-016-1223-z.

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 Creators:
Pelzer, Esther A.1, Author              
Melzer, Corina1, Author              
Timmermann, Lars, Author
von Cramon, D. Yves2, Author              
Tittgemeyer, Marc1, Author              
Affiliations:
1Translational Neurocircuitry, Research Groups, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society, ou_2149668              
2Von Cramon-Literatur, Max-Planck-Institut für neurologische Forschung, Managing Director: D. Yves von Cramon, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society, ou_2149664              

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 Abstract: Basal ganglia and the cerebellum are part of a densely interconnected network. While both subcortical structures process information in basically segregated loops that primarily interact in the neocortex, direct subcortical interaction has been recently confirmed by neuroanatomical studies using viral transneuronal tracers in non-human primate brains. The thalamus is thought to be the main relay station of both projection systems. Yet, our understanding of subcortical basal ganglia and cerebellar interconnectivity within the human thalamus is rather sparse, primarily due to limitation in the acquisition of in vivo tracing. Consequently, we strive to characterize projections of both systems and their potential overlap within the human thalamus by diffusion MRI and tractography. Our analysis revealed a decreasing anterior-to-posterior gradient for pallido-thalamic connections in: (1) the ventral-anterior thalamus, (2) the intralaminar nuclei, and (3) midline regions. Conversely, we found a decreasing posterior-to-anterior gradient for dentato-thalamic projections predominantly in: (1) the ventral-lateral and posterior nucleus; (2) dorsal parts of the intralaminar nuclei and the subparafascicular nucleus, and (3) the medioventral and lateral mediodorsal nucleus. A considerable overlap of connectivity pattern was apparent in intralaminar nuclei and midline regions. Notably, pallidal and cerebellar projections were both hemispherically lateralized to the left thalamus. While strikingly consistent with findings from transneuronal studies in non-human primates as well as with pre-existing anatomical studies on developmentally expressed markers or pathological human brains, our assessment provides distinctive connectional fingerprints that illustrate the anatomical substrate of integrated functional networks between basal ganglia and the cerebellum. Thereby, our findings furnish useful implications for cerebellar contributions to the clinical symptomatology of movement disorders. © 2016 The Author(s)

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Language(s): eng - English
 Dates: 2017
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1007/s00429-016-1223-z
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Title: Brain Structure & Function
  Abbreviation : Brain Struct Funct
Source Genre: Journal
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Publ. Info: Berlin : Springer
Pages: - Volume / Issue: 222 (1) Sequence Number: - Start / End Page: 381 - 392 Identifier: ISSN: 1863-2653
CoNE: https://pure.mpg.de/cone/journals/resource/1863-2653