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  Functional organization of sensory input to the olfactory bulb glomerulus analyzed by two-photon calcium imaging

Wachowiak, M., Denk, W., & Friedrich, R. W. (2004). Functional organization of sensory input to the olfactory bulb glomerulus analyzed by two-photon calcium imaging. Proceedings of the National Academy of Sciences of the United States of America, 101(24), 9097-9102. doi:10.1073/pnas.0400438101.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-5F28-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-5F29-F
Genre: Journal Article
Alternative Title : Functional organization of sensory input to the olfactory bulb glomerulus analyzed by two-photon calcium imaging

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PNAS_101_2004_9097.pdf (Any fulltext), 475KB
 
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 Creators:
Wachowiak, Matt, Author
Denk, Winfried1, Author              
Friedrich, Rainer W.1, Author              
Affiliations:
1Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              

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 Abstract: Glomeruli in the olfactory bulb are anatomically discrete modules receiving input from idiotypic olfactory sensory neurons. To examine the functional organization of sensory inputs to individual glomeruli, we loaded olfactory sensory neurons with a Ca(2+) indicator and measured odorant-evoked presynaptic Ca(2+) signals within single glomeruli by using two-photon microscopy in anaesthetized mice. Odorants evoked patterns of discrete Ca(2+) signals throughout the neuropil of a glomerulus. Across glomeruli, Ca(2+) signals occurred with equal probability in all glomerular regions. Within single glomeruli, the pattern of intraglomerular Ca(2+) signals was indistinguishable for stimuli of different duration, identity, and concentration. Moreover, the response time course of the signals was similar throughout the glomerulus. Hence, sensory inputs to individual glomeruli are spatially heterogeneous but seem to be functionally indiscriminate. These results support the view of olfactory glomeruli as functional units in representing sensory information.

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Language(s): eng - English
 Dates: 2004-01-202004-05-102004-06-072004-06-15
 Publication Status: Published in print
 Pages: 6
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 Table of Contents: -
 Rev. Type: Peer
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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proc. Natl. Acad. Sci. U. S. A.
Source Genre: Journal
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Publ. Info: National Academy of Sciences
Pages: - Volume / Issue: 101 (24) Sequence Number: - Start / End Page: 9097 - 9102 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230