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  Boosting of action potential backpropagation by neocortical network activity in vivo

Waters, D. J., & Helmchen, F. (2004). Boosting of action potential backpropagation by neocortical network activity in vivo. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience, 24(49), 11127-11136. doi:10.1523/JNEUROSCI.2933-04.2004.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002A-617F-F Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002A-6180-9
Genre: Journal Article
Alternative Title : Boosting of action potential backpropagation by neocortical network activity in vivo

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 Creators:
Waters, David Jack1, Author           
Helmchen, Fritjof1, Author           
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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Free keywords: dendrite; two-photon; calcium; layer 2/3; up state; pyramidal neuron
 Abstract: Action potentials backpropagate into the dendritic trees of pyramidal neurons, reporting output activity to the sites of synaptic input and provoking long-lasting changes in synaptic strength. It is unclear how this retrograde signal is modified by neural network activity. Using whole-cell recordings from somata, apical trunks, and dendritic tuft branches of layer 2/3 pyramidal neurons in vivo, we show that network-driven subthreshold membrane depolarizations ("up states") occur simultaneously throughout the apical dendritic tree. This spontaneous synaptic activity enhances action potential-evoked calcium influx into the distal apical dendrite by promoting action potential backpropagation. Hence, somatic feedback to the dendrites becomes stronger with increasing network activity.

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Language(s): eng - English
 Dates: 2004-10-212004-07-202004-10-222004-12-08
 Publication Status: Issued
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 665565
DOI: 10.1523/JNEUROSCI.2933-04.2004
URI: http://www.ncbi.nlm.nih.gov/pubmed/15590929
URI: http://www.jneurosci.org/content/24/49/11127
URI: http://www.jneurosci.org/content/24/49/11127.full
Other: 6434
 Degree: -

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Title: The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
  Other : J. Neurosci.
Source Genre: Journal
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Publ. Info: Baltimore, MD : The Society
Pages: - Volume / Issue: 24 (49) Sequence Number: - Start / End Page: 11127 - 11136 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1