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  Leptin substitution in patients with lipodystrophy: Neural correlates for long-term success in the normalization of eating behavior

Schlögl, H., Mueller, K., Horstmann, A., Miehle, K., Püschel, J., Villringer, A., et al. (2016). Leptin substitution in patients with lipodystrophy: Neural correlates for long-term success in the normalization of eating behavior. Diabetes, 65(8), 2179-2186. doi:10.2337/db15-1550.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-6384-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-19B1-9
Genre: Journal Article

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 Creators:
Schlögl, Haiko1, Author              
Mueller, Karsten2, Author              
Horstmann, Annette3, 4, Author              
Miehle, Konstanze1, Author
Püschel, Janett1, 3, Author
Villringer, Arno4, 5, Author              
Pleger, Burkhard4, 6, Author              
Stumvoll, Michael1, Author
Faßhauer, Mathias1, 3, Author
Affiliations:
1Faculty of Medicine, University of Leipzig, Germany, ou_persistent22              
2Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
3Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
5Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
6Department of Neurology, University Hospital Bergmannsheil, Bochum, Germany, ou_persistent22              

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 Abstract: Lipodystrophy (LD) is a rare disease with a paucity of subcutaneous adipocytes and leptin-deficiency. Patients often develop severe diabetes mellitus and show disturbed eating behavior with reduced satiety that can be restored by substitution with the leptin analogue metreleptin. However, long-term effects of metreleptin on resting-state brain connectivity in treatment-naïve LD patients have not been assessed. In this study, resting-state functional magnetic resonance imaging (fMRI) scans and extensive behavioral testing assessing changes in hunger/satiety regulation were performed during the first 52 weeks of metreleptin treatment in nine LD patients. Resting-state connectivity significantly increased over the course of metreleptin treatment in three brain areas, i.e. hypothalamus, insula/superior temporal gyrus, and medial prefrontal cortex. Behavioral tests demonstrated that perceived hunger, importance of eating, eating frequencies, and liking ratings of food pictures significantly decreased during metreleptin therapy. Taken together, leptin substitution was accompanied by long-term changes of hedonic and homeostatic central nervous networks regulating eating behavior, as well as decreased hunger feelings and diminished incentive value of food. It needs to be assessed in future studies whether metreleptin treatment in LD restores physiological processes important for the development of satiety.

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Language(s): eng - English
 Dates: 2015-11-092016-05-032016-05-102016-08
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.2337/db15-1550
PMID: 27207511
Other: Epub 2016
 Degree: -

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Title: Diabetes
Source Genre: Journal
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Publ. Info: New York : American Diabetes Association
Pages: - Volume / Issue: 65 (8) Sequence Number: - Start / End Page: 2179 - 2186 Identifier: ISSN: 0012-1797
CoNE: /journals/resource/110978977971732