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  Leptin substitution in patients with lipodystrophy: Neural correlates for long-term success in the normalization of eating behavior

Schlögl, H., Mueller, K., Horstmann, A., Miehle, K., Püschel, J., Villringer, A., et al. (2016). Leptin substitution in patients with lipodystrophy: Neural correlates for long-term success in the normalization of eating behavior. Diabetes, 65(8), 2179-2186. doi:10.2337/db15-1550.

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Genre: Zeitschriftenartikel

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externe Referenz:
https://doi.org/10.2337/db15-1550 (Verlagsversion)
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OA-Status:
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 Urheber:
Schlögl, Haiko1, Autor           
Mueller, Karsten2, Autor           
Horstmann, Annette3, 4, Autor           
Miehle, Konstanze1, Autor
Püschel, Janett1, 3, Autor
Villringer, Arno4, 5, Autor           
Pleger, Burkhard4, 6, Autor           
Stumvoll, Michael1, Autor
Faßhauer, Mathias1, 3, Autor
Affiliations:
1Faculty of Medicine, University of Leipzig, Germany, ou_persistent22              
2Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
3Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
5Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
6Department of Neurology, University Hospital Bergmannsheil, Bochum, Germany, ou_persistent22              

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Schlagwörter: Adult; Brain; Feeding Behavior; Female; Humans; Hunger; Leptin; Lipodystrophy; Magnetic Resonance Imaging; Male; Satiation
 Zusammenfassung: Lipodystrophy (LD) is a rare disease with a paucity of subcutaneous adipocytes and leptin-deficiency. Patients often develop severe diabetes mellitus and show disturbed eating behavior with reduced satiety that can be restored by substitution with the leptin analogue metreleptin. However, long-term effects of metreleptin on resting-state brain connectivity in treatment-naïve LD patients have not been assessed. In this study, resting-state functional magnetic resonance imaging (fMRI) scans and extensive behavioral testing assessing changes in hunger/satiety regulation were performed during the first 52 weeks of metreleptin treatment in nine LD patients. Resting-state connectivity significantly increased over the course of metreleptin treatment in three brain areas, i.e. hypothalamus, insula/superior temporal gyrus, and medial prefrontal cortex. Behavioral tests demonstrated that perceived hunger, importance of eating, eating frequencies, and liking ratings of food pictures significantly decreased during metreleptin therapy. Taken together, leptin substitution was accompanied by long-term changes of hedonic and homeostatic central nervous networks regulating eating behavior, as well as decreased hunger feelings and diminished incentive value of food. It needs to be assessed in future studies whether metreleptin treatment in LD restores physiological processes important for the development of satiety.

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Sprache(n): eng - English
 Datum: 2015-11-092016-05-032016-05-102016-08
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.2337/db15-1550
PMID: 27207511
Anderer: Epub 2016
 Art des Abschluß: -

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Projektname : -
Grant ID : 82DZD00601
Förderprogramm : -
Förderorganisation : Deutsches Zentrum für Diabetesforschung
Projektname : -
Grant ID : 01EO1501; K6a-87; K7-83; K7-84
Förderprogramm : IFB AdiposityDiseases grant
Förderorganisation : Institut Français de Bioinformatique (IFB)
Projektname : -
Grant ID : CRC 1052
Förderprogramm : -
Förderorganisation : Deutsche Forschungsgemeinschaft (DFG)
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Bundesministerium für Bildung und Forschung (BMBF)

Quelle 1

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Titel: Diabetes
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: New York : American Diabetes Association
Seiten: - Band / Heft: 65 (8) Artikelnummer: - Start- / Endseite: 2179 - 2186 Identifikator: ISSN: 0012-1797
CoNE: https://pure.mpg.de/cone/journals/resource/110978977971732