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  Leptin substitution in patients with lipodystrophy: Neural correlates for long-term success in the normalization of eating behavior

Schlögl, H., Mueller, K., Horstmann, A., Miehle, K., Püschel, J., Villringer, A., et al. (2016). Leptin substitution in patients with lipodystrophy: Neural correlates for long-term success in the normalization of eating behavior. Diabetes, 65(8), 2179-2186. doi:10.2337/db15-1550.

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Locator:
https://doi.org/10.2337/db15-1550 (Publisher version)
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OA-Status:
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 Creators:
Schlögl, Haiko1, Author           
Mueller, Karsten2, Author           
Horstmann, Annette3, 4, Author           
Miehle, Konstanze1, Author
Püschel, Janett1, 3, Author
Villringer, Arno4, 5, Author           
Pleger, Burkhard4, 6, Author           
Stumvoll, Michael1, Author
Faßhauer, Mathias1, 3, Author
Affiliations:
1Faculty of Medicine, University of Leipzig, Germany, ou_persistent22              
2Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
3Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
5Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
6Department of Neurology, University Hospital Bergmannsheil, Bochum, Germany, ou_persistent22              

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Free keywords: Adult; Brain; Feeding Behavior; Female; Humans; Hunger; Leptin; Lipodystrophy; Magnetic Resonance Imaging; Male; Satiation
 Abstract: Lipodystrophy (LD) is a rare disease with a paucity of subcutaneous adipocytes and leptin-deficiency. Patients often develop severe diabetes mellitus and show disturbed eating behavior with reduced satiety that can be restored by substitution with the leptin analogue metreleptin. However, long-term effects of metreleptin on resting-state brain connectivity in treatment-naïve LD patients have not been assessed. In this study, resting-state functional magnetic resonance imaging (fMRI) scans and extensive behavioral testing assessing changes in hunger/satiety regulation were performed during the first 52 weeks of metreleptin treatment in nine LD patients. Resting-state connectivity significantly increased over the course of metreleptin treatment in three brain areas, i.e. hypothalamus, insula/superior temporal gyrus, and medial prefrontal cortex. Behavioral tests demonstrated that perceived hunger, importance of eating, eating frequencies, and liking ratings of food pictures significantly decreased during metreleptin therapy. Taken together, leptin substitution was accompanied by long-term changes of hedonic and homeostatic central nervous networks regulating eating behavior, as well as decreased hunger feelings and diminished incentive value of food. It needs to be assessed in future studies whether metreleptin treatment in LD restores physiological processes important for the development of satiety.

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Language(s): eng - English
 Dates: 2015-11-092016-05-032016-05-102016-08
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.2337/db15-1550
PMID: 27207511
Other: Epub 2016
 Degree: -

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Project name : -
Grant ID : 82DZD00601
Funding program : -
Funding organization : Deutsches Zentrum für Diabetesforschung
Project name : -
Grant ID : 01EO1501; K6a-87; K7-83; K7-84
Funding program : IFB AdiposityDiseases grant
Funding organization : Institut Français de Bioinformatique (IFB)
Project name : -
Grant ID : CRC 1052
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Bundesministerium für Bildung und Forschung (BMBF)

Source 1

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Title: Diabetes
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York : American Diabetes Association
Pages: - Volume / Issue: 65 (8) Sequence Number: - Start / End Page: 2179 - 2186 Identifier: ISSN: 0012-1797
CoNE: https://pure.mpg.de/cone/journals/resource/110978977971732