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  Selective Persistence of Sensorimotor Mismatch Signals in Visual Cortex of Behaving Alzheimer's Disease Mice

Liebscher, S., Keller, G. B., Goltstein, P. M., Bonhoeffer, T., & Hübener, M. (2016). Selective Persistence of Sensorimotor Mismatch Signals in Visual Cortex of Behaving Alzheimer's Disease Mice. CURRENT BIOLOGY, 26(7), 956-964. doi:10.1016/j.cub.2016.01.070.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-6FB6-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-6FB7-0
Genre: Journal Article

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 Creators:
Liebscher, Sabine1, Author              
Keller, Georg B.1, Author              
Goltstein, Pieter M.1, Author              
Bonhoeffer, Tobias1, Author              
Hübener, Mark1, Author              
Affiliations:
1Department: Synapses-Circuits-Plasticity / Bonhoeffer, MPI of Neurobiology, Max Planck Society, ou_1113545              

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Free keywords: NORADRENERGIC LOCUS-COERULEUS; MOUSE MODEL; FUNCTIONAL CONNECTIVITY; AUTONOMIC FUNCTION; AMYLOID PLAQUES; IN-VIVO; BRAIN; STATE; MODULATION; NEUROANATOMY
 Abstract: Neurodegenerative processes in Alzheimer's disease (AD) affect the structure and function of neurons [1-4], resulting in altered neuronal activity patterns comprising neuronal hypo- and hyperactivity [5, 6] and causing the disruption of long-range projections [7, 8]. Impaired information processing between functionally connected brain areas is evident in defective visuomotor integration, an early sign of the disease [9-11]. The cellular and neuronal circuit mechanisms underlying this disruption of information processing in AD, however, remain elusive. Recent studies in mice suggest that visuomotor integration already occurs in primary visual cortex (V1), as it not only processes sensory input but also exhibits strong motor-related activity, likely driven by neuromodulatory or excitatory inputs [12-17]. Here, we probed the integration of visual-and motor-related-inputs in V1 of behaving APP/PS1 [18] mice, a well-characterized mouse model of AD, using two-photon calcium imaging. We find that sensorimotor signals in APP/PS1 mice are differentially affected: while visually driven and motor-related signals are strongly reduced, neuronal responses signaling a mismatch between expected and actual visual flow are selectively spared. We furthermore observe an increase in aberrant activity during quiescent states in APP/PS1 mice. Jointly, the reduction in running-correlated activity and the enhanced aberrant activity degrade the coding accuracy of the network, indicating that the impairment of visuomotor integration in AD is already taking place at early stages of visual processing.

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Language(s): eng - English
 Dates: 2016
 Publication Status: Published in print
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: ISI: 000373273600032
DOI: 10.1016/j.cub.2016.01.070
 Degree: -

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Title: CURRENT BIOLOGY
Source Genre: Journal
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Publ. Info: 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA : CELL PRESS
Pages: - Volume / Issue: 26 (7) Sequence Number: - Start / End Page: 956 - 964 Identifier: ISSN: 0960-9822