English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Comprehensive Characterization of the Major Presynaptic Elements to the Drosophila OFF Motion Detector

Serbe, E., Meier, M., Leonhardt, A., & Borst, A. (2016). Comprehensive Characterization of the Major Presynaptic Elements to the Drosophila OFF Motion Detector. NEURON, 89(4), 829-841. doi:10.1016/j.neuron.2016.01.006.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Serbe, Etienne1, Author              
Meier, Matthias1, Author              
Leonhardt, Aljoscha1, Author              
Borst, Alexander1, Author              
Affiliations:
1Department: Circuits-Computation-Models / Borst, MPI of Neurobiology, Max Planck Society, ou_1113548              

Content

show
hide
Free keywords: RETINAL GANGLION-CELLS; VISUAL-SYSTEM; FUNCTIONAL SPECIALIZATION; DIRECTION SELECTIVITY; NEURAL CIRCUIT; FLY; VISION; INTERNEURONS; EXPRESSION; PATHWAYS
 Abstract: Estimating motion is a fundamental task for the visual system of sighted animals. In Drosophila, direction-selective T4 and T5 cells respond to moving brightness increments (ON) and decrements (OFF), respectively. Current algorithmic models of the circuit are based on the interaction of two differentially filtered signals. However, electron microscopy studies have shown that T5 cells receive their major input from four classes of neurons: Tm1, Tm2, Tm4, and Tm9. Using two-photon calcium imaging, we demonstrate that T5 is the first direction-selective stage within the OFF pathway. The four cells provide an array of spatiotemporal filters to T5. Silencing their synaptic output in various combinations, we find that all input elements are involved in OFF motion detection to varying degrees. Our comprehensive survey challenges the simplified view of how neural systems compute the direction of motion and suggests that an intricate interplay of many signals results in direction selectivity.

Details

show
hide
Language(s): eng - English
 Dates: 2016
 Publication Status: Published in print
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: NEURON
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA : CELL PRESS
Pages: - Volume / Issue: 89 (4) Sequence Number: - Start / End Page: 829 - 841 Identifier: ISSN: 0896-6273