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  Comprehensive Characterization of the Major Presynaptic Elements to the Drosophila OFF Motion Detector

Serbe, E., Meier, M., Leonhardt, A., & Borst, A. (2016). Comprehensive Characterization of the Major Presynaptic Elements to the Drosophila OFF Motion Detector. NEURON, 89(4), 829-841. doi:10.1016/j.neuron.2016.01.006.

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 Creators:
Serbe, Etienne1, Author           
Meier, Matthias1, Author           
Leonhardt, Aljoscha1, Author           
Borst, Alexander1, Author           
Affiliations:
1Department: Circuits-Computation-Models / Borst, MPI of Neurobiology, Max Planck Society, ou_1113548              

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Free keywords: RETINAL GANGLION-CELLS; VISUAL-SYSTEM; FUNCTIONAL SPECIALIZATION; DIRECTION SELECTIVITY; NEURAL CIRCUIT; FLY; VISION; INTERNEURONS; EXPRESSION; PATHWAYS
 Abstract: Estimating motion is a fundamental task for the visual system of sighted animals. In Drosophila, direction-selective T4 and T5 cells respond to moving brightness increments (ON) and decrements (OFF), respectively. Current algorithmic models of the circuit are based on the interaction of two differentially filtered signals. However, electron microscopy studies have shown that T5 cells receive their major input from four classes of neurons: Tm1, Tm2, Tm4, and Tm9. Using two-photon calcium imaging, we demonstrate that T5 is the first direction-selective stage within the OFF pathway. The four cells provide an array of spatiotemporal filters to T5. Silencing their synaptic output in various combinations, we find that all input elements are involved in OFF motion detection to varying degrees. Our comprehensive survey challenges the simplified view of how neural systems compute the direction of motion and suggests that an intricate interplay of many signals results in direction selectivity.

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Language(s): eng - English
 Dates: 2016
 Publication Status: Issued
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: NEURON
Source Genre: Journal
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Publ. Info: 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA : CELL PRESS
Pages: - Volume / Issue: 89 (4) Sequence Number: - Start / End Page: 829 - 841 Identifier: ISSN: 0896-6273