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  Control of synaptic strength and timing by the release-site Ca2+ signal

Bollmann, J. H., & Sakmann, B. (2005). Control of synaptic strength and timing by the release-site Ca2+ signal. Nature Neuroscience, 8(4), 426-434. doi:10.1038/nn1417.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-6CDF-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-6CE1-E
Genre: Journal Article
Alternative Title : Control of synaptic strength and timing by the release-site Ca2+ signal

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NatNeurosci_8_2005_426.pdf (Any fulltext), 754KB
 
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 Creators:
Bollmann, Johann H.1, Author              
Sakmann, Bert1, Author              
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1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Abstract: Transmitter release is triggered by highly localized, transient increases in the presynaptic Ca2+ concentration ([Ca2+]). Rapidly decaying [Ca2+] elevations were generated using Ca2+ uncaging techniques, and [Ca2+] was measured with a low-affinity Ca2+ indicator in a giant presynaptic terminal, the calyx of Held, in rat brain slices. The rise time and amplitude of evoked excitatory postsynaptic currents (EPSCs) depended on the half-width of the fluorescence transient, which was predicted by a five-binding site model of a Ca2+ sensor having relatively high affinity (Kd approx13 muM). Very fast [Ca2+] transients (half-width <0.5 ms) evoked EPSCs similar to those elicited by a single action potential (AP) in the same synapse. Triggering release with dual [Ca2+] transients of variable amplitudes demonstrated the supralinear transfer function of the sensor. The sensitivity of release to the time course of the [Ca2+] transient may contribute to mechanisms by which the presynaptic AP waveform controls synaptic strength.

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Language(s): eng - English
 Dates: 2004-10-142005-02-152005-03-062005-04-01
 Publication Status: Published in print
 Pages: 9
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 Table of Contents: -
 Rev. Type: Peer
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Title: Nature Neuroscience
  Other : Nat. Neurosci.
Source Genre: Journal
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Publ. Info: New York, NY : Nature America Inc.
Pages: - Volume / Issue: 8 (4) Sequence Number: - Start / End Page: 426 - 434 Identifier: ISSN: 1097-6256
CoNE: https://pure.mpg.de/cone/journals/resource/954925610931