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  Olfactory microcircuits

Friedrich, R. W., Firestein, S., Galizia, C. G., Greer, C. A., Laurent, G., Lledo, P.-M., et al. (2006). Olfactory microcircuits. In S. Grillner, & A. M. Graybiel (Eds.), Microcircuits:The Interface between Neurons and Global Brain Function (pp. 275-294). Cambridge, MA: MIT.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-6ED3-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-6EDD-4
Genre: Book Chapter
Alternative Title : Olfactory microcircuits

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MicrocircuitsInterfacNeuronGlobalBrainFunctions_2006_chpt14.pdf (Any fulltext), 115KB
 
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 Creators:
Friedrich, Rainer W.1, Author              
Firestein, S., Author
Galizia, C. G., Author
Greer, C. A., Author
Laurent, Gilles, Author
Lledo, Pierre-Marie, Author
Mombaerts, P., Author
Sachse, S., Author
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1Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              

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 Abstract: 14 Group Report: Olfactory Microcircuits R. W. F RIEDRICH , Rapporteur S. F IRESTEIN ,C.G.G ALIZIA ,C.A.G REER ,G.L AURENT , P. - M . L LEDO ,P.M OMBAERTS ,andS.S ACHSE OVERVIEW Most organisms rely on an olfactory system to detect and analyze chemical cues in the environment in the context of essential behaviors. The basic layout of the first processing centers in the olfactory nervous system is remarkably similar in diverse phylogenetic classes, including insects and vertebrates. Chemicals are detected by odorant receptor proteins expressed by olfactory sensory neurons (OSNs), which send an axon to the first processing center in the brain, the olfac- tory bulb in vertebrates and the antennal lobe in insects. OSNs terminate in ana- tomically distinct input modules, the olfactory glomeruli. In all vertebrate and invertebrate species investigated to date, each OSN expresses only one or a few odorant receptors, and each glomerulus receives convergent input from only one type of OSN. Glomeruli are, therefore, considered functional units integrat - ing sensory input from idiotypic afferents. Even simple odors stimulate multiple odorant receptors and thus evoke odor-specific patterns of afferent activity across the array of glomeruli. Within glomeruli, OSNs make excitatory synap - ses onto the output neurons, the mitral cells in vertebrates, and projection neu - rons in insects, as well as with local inhibitory interneurons. As a result of synap - tic interactions within this network, the output of a given projection neuron is not simply determined by the sensory input to the glomeruli it innervates, but also by the activity of inputs channeled through other glomeruli. In addition, synaptic interactions temporally pattern olfactory bulb/antennal lobe output ac - tivity on at least two timescales. It is currently debated how odor information is encoded in the olfactory bulb/antennal lobe, and how neuronal circuits process odor information conveyed by sensory afferents. Moreover, the development and plasticity of olfactory circuits are only beginning to be elucidated. These issues are of particular interest because OSNs and interneurons in the olfactory bulb undergo continuous turnover throughout life in vertebrates

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Language(s): eng - English
 Dates: 20062006-08-11
 Publication Status: Published in print
 Pages: 20
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 665770
Other: 6145
 Degree: -

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Title: Microcircuits:The Interface between Neurons and Global Brain Function
Source Genre: Book
 Creator(s):
Grillner, S., Editor
Graybiel, A. M., Editor
Affiliations:
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Publ. Info: Cambridge, MA : MIT
Pages: - Volume / Issue: 1. Auflage Sequence Number: - Start / End Page: 275 - 294 Identifier: ISBN: 0262072785
ISBN: 978-0819427953