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  Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer.

Akoury, E., Mukrasch, M., Biernat, J., Tepper, K., Ozenne, V., Mandelkow, E., et al. (2016). Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer. Protein Science, 25(5), 1010-1020. doi:10.1002/pro.2911.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-713C-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-7142-5
Genre: Journal Article

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 Creators:
Akoury, E.1, Author              
Mukrasch, M.2, Author              
Biernat, J., Author
Tepper, K., Author
Ozenne, V., Author
Mandelkow, E., Author
Blackledge, M., Author
Zweckstetter, M.1, Author              
Affiliations:
1Research Group of Protein Structure Determination using NMR, MPI for biophysical chemistry, Max Planck Society, ou_578571              
2Department of NMR Based Structural Biology, MPI for biophysical chemistry, Max Planck Society, ou_578567              

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Free keywords: Alzheimer disease; NMR spectroscopy; Tau; protein misfolding; structure
 Abstract: Misfolding of the microtubule-associated protein Tau is a hallmark of Alzheimer disease and several other neurodegenerative disorders. Because of the dynamic nature of the Tau protein, little is known about the changes in Tau structure that occur during misfolding. Here we studied the structural consequences upon binding of the repeat domain of Tau, which plays a key role in pathogenic aggregation, to an aggregation enhancer. By combining NMR experiments with molecular simulations we show that binding of the aggregation enhancer polyglutamic acid remodels the conformational ensemble of Tau. Our study thus provides insight into an early event during misfolding of Tau.

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Language(s): eng - English
 Dates: 2016-03-032016-05
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1002/pro.2911
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Title: Protein Science
Source Genre: Journal
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Pages: - Volume / Issue: 25 (5) Sequence Number: - Start / End Page: 1010 - 1020 Identifier: -