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  Second harmonic generation imaging of collagen fibrils in cornea and sclera

Han, M., Giese, G., & Bille, J. F. (2005). Second harmonic generation imaging of collagen fibrils in cornea and sclera. Optics Express, 13(15), 5791-5797. doi:10.1364/OPEX.13.005791.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-7150-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-7151-3
Genre: Journal Article
Alternative Title : Second harmonic generation imaging of collagen fibrils in cornea and sclera

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OptExpress_13_2005_5791.pdf (Any fulltext), 481KB
 
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 Creators:
Han, Meng, Author
Giese, Günter1, Author              
Bille, Josef F., Author
Affiliations:
1Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              

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Free keywords: (140.7090) Lasers and laser optics : Ultrafast lasers (170.4460) Medical optics and biotechnology : Ophthalmic optics (170.4470) Medical optics and biotechnology : Ophthalmology (180.5810) Microscopy : Scanning microscopy (190.1900) Nonlinear optics : Diagnostic applications of nonlinear optics
 Abstract: Collagen, as the most abundant protein in the human body, determines the unique physiological and optical properties of the connective tissues including cornea and sclera. The ultrastructure of collagen, which conventionally can only be resolved by electron microscopy, now can be probed by optical second harmonic generation (SHG) imaging. SHG imaging revealed that corneal collagen fibrils are regularly packed as a polycrystalline lattice, accounting for the transparency of cornea. In contrast, scleral fibrils possess inhomogeneous, tubelike structures with thin hard shells, maintaining the high stiffness and elasticity of the sclera.

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Language(s): eng - English
 Dates: 2005-07-082005-05-252005-07-192005-07-25
 Publication Status: Published in print
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
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Title: Optics Express
Source Genre: Journal
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Publ. Info: Washington, DC : Optical Society of America
Pages: - Volume / Issue: 13 (15) Sequence Number: - Start / End Page: 5791 - 5797 Identifier: ISSN: 1094-4087
CoNE: https://pure.mpg.de/cone/journals/resource/954925609918