English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The primordial, blue-cone color system of the mouse retina

Haverkamp, S., Waessle, H., Dübel, J., Kuner, T., Augustine, G. J., Feng, G., et al. (2005). The primordial, blue-cone color system of the mouse retina. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience, 25(22), 5438-5445. doi:10.1523/JNEUROSCI.1117-05.2005.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-719F-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-71A0-2
Genre: Journal Article
Alternative Title : The primordial, blue-cone color system of the mouse retina

Files

show Files
hide Files
:
JNeurosci_25_2005_5438.pdf (Any fulltext), 490KB
 
File Permalink:
-
Name:
JNeurosci_25_2005_5438.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-
Description:
-

Creators

show
hide
 Creators:
Haverkamp, Silke, Author
Waessle, Heinz, Author
Dübel, Jens1, Author              
Kuner, Thomas2, Author              
Augustine, George J., Author
Feng, Guoping, Author
Euler, Thomas1, Author              
Affiliations:
1Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              
2Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

Content

show
hide
Free keywords: retina; S-cones; L-cones; color vision; bipolar cells; mice
 Abstract: Humans and old world primates have trichromatic color vision based on three spectral types of cone [long-wavelength (L-), middle-wavelength (M-), and short-wavelength (S-) cones]. All other placental mammals are dichromats, and their color vision depends on the comparison of L- and S-cone signals; however, their cone-selective retinal circuitry is still unknown. Here, we identified the S-cone-selective (blue cone) bipolar cells of the mouse retina. They were labeled in a transgenic mouse expressing Clomeleon, a chloride-sensitive fluorescent protein, under the control of the thy1 promoter. Blue-cone bipolar cells comprise only 1-2% of the bipolar cell population, and their dendrites selectively contact S-opsin-expressing cones. In the dorsal half of the mouse retina, only 3-5% of the cones express S-opsin, and they are all contacted by blue-cone bipolar cells, whereas all L-opsin-expressing cones (approximately 95%) are avoided. In the ventral mouse retina, the great majority of cones express both S- and L-opsin. They are not contacted by blue-cone bipolar cells. A minority of ventral cones express S-opsin only, and they are selectively contacted by blue-cone bipolar cells. We suggest that these are genuine S-cones. In contrast to the other cones, their pedicles contain only low amounts of cone arrestin. The blue-cone bipolar cells of the mouse retina and their cone selectivity are closely similar to primate blue-cone bipolars, and we suggest that they both represent the phylogenetically ancient color system of the mammalian retina.

Details

show
hide
Language(s): eng - English
 Dates: 2005-04-252005-03-222005-04-282005-06-01
 Publication Status: Published in print
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
  Other : J. Neurosci.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Baltimore, MD : The Society
Pages: - Volume / Issue: 25 (22) Sequence Number: - Start / End Page: 5438 - 5445 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1