English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Risk factors for addiction and their association with model-based behavioral control

Reiter, A., Deserno, L., Wilbertz, T., Heinze, H.-J., & Schlagenhauf, F. (2016). Risk factors for addiction and their association with model-based behavioral control. Frontiers in Behavioral Neuroscience, 10: 26. doi:10.3389/fnbeh.2016.00026.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-8C05-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-1E3F-7
Genre: Journal Article

Files

show Files
hide Files
:
Reiter_2016.pdf (Publisher version), 2MB
Name:
Reiter_2016.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Reiter, Andrea1, 2, Author              
Deserno, Lorenz1, 3, 4, Author              
Wilbertz, Tilmann1, Author
Heinze, Hans-Jochen1, 4, 5, Author
Schlagenhauf, Florian1, 3, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
2Lifespan Developmental Neuroscience, Department of Psychology, TU Dresden, Germany, ou_persistent22              
3Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany, ou_persistent22              
4Department of Neurology, Otto von Guericke University Magdeburg, Germany, ou_persistent22              
5Department of Behavioral Neurology, Leibniz Institute for Neurobiology, Magdeburg, Germany, ou_persistent22              

Content

show
hide
Free keywords: Decision-making; Instrumental control; Addiction; Alcohol; Family history; Risk; Impulsivity; Cognitive capacity
 Abstract: Addiction shows familial aggregation and previous endophenotype research suggests that healthy relatives of addicted individuals share altered behavioral and cognitive characteristics with individuals suffering from addiction. In this study we asked whether impairments in behavioral control proposed for addiction, namely a shift from goal-directed, model-based toward habitual, model-free control, extends toward an unaffected sample (n = 20) of adult children of alcohol-dependent fathers as compared to a sample without any personal or family history of alcohol addiction (n = 17). Using a sequential decision-making task designed to investigate model-free and model-based control combined with a computational modeling analysis, we did not find any evidence for altered behavioral control in individuals with a positive family history of alcohol addiction. Independent of family history of alcohol dependence, we however observed that the interaction of two different risk factors of addiction, namely impulsivity and cognitive capacities, predicts the balance of model-free and model-based behavioral control. Post-hoc tests showed a positive association of model-based behavior with cognitive capacity in the lower, but not in the higher impulsive group of the original sample. In an independent sample of particularly high- vs. low-impulsive individuals, we confirmed the interaction effect of cognitive capacities and high vs. low impulsivity on model-based control. In the confirmation sample, a positive association of omega with cognitive capacity was observed in highly impulsive individuals, but not in low impulsive individuals. Due to the moderate sample size of the study, further investigation of the association of risk factors for addiction with model-based behavior in larger sample sizes is warranted.

Details

show
hide
Language(s): eng - English
 Dates: 2015-10-222016-02-042016-03-17
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3389/fnbeh.2016.00026
PMID: 27013998
PMC: PMC4794491
Other: eCollection 2016
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Frontiers in Behavioral Neuroscience
  Abbreviation : Front Behav Neurosci
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 10 Sequence Number: 26 Start / End Page: - Identifier: Other: 1662-5153
CoNE: /journals/resource/1662-5153