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  Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005). Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science, 308(5726), 1314-1318. doi:10.1126/science.1110647.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002A-C42F-D Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002A-C430-7
Genre: Journal Article
Alternative Title : Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

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Science_308_2005_1314.pdf (Any fulltext), 446KB
 
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 Creators:
Nimmerjahn, Axel1, Author           
Kirchhoff, Frank, Author
Helmchen, Fritjof1, Author           
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Abstract: Microglial cells represent the immune system of the mammalian brain and therefore are critically involved in various injuries and diseases. Little is known about their role in the healthy brain and their immediate reaction to brain damage. By using in vivo two-photon imaging in neocortex, we found that microglial cells are highly active in their presumed resting state, continually surveying their microenvironment with extremely motile processes and protrusions. Furthermore, blood-brain barrier disruption provoked immediate and focal activation of microglia, switching their behavior from patroling to shielding of the injured site. Microglia thus are busy and vigilant housekeepers in the adult brain.

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Language(s): eng - English
 Dates: 2005-02-032005-03-172005-05-27
 Publication Status: Issued
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 665552
DOI: 10.1126/science.1110647
URI: http://www.ncbi.nlm.nih.gov/pubmed/15831717
URI: http://science.sciencemag.org/content/308/5726/1314
URI: http://science.sciencemag.org/content/308/5726/1314.full
Other: 6432
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Title: Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 308 (5726) Sequence Number: - Start / End Page: 1314 - 1318 Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1