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  Restoration of spatial working memory by genetic rescue of GluR-A-deficient mice

Schmitt, W. B., Sprengel, R., Mack, V., Draft, R., Seeburg, P. H., Deacon, R. M. J., et al. (2005). Restoration of spatial working memory by genetic rescue of GluR-A-deficient mice. Nature Neuroscience, 8(3), 270-272. doi:10.1038/nn1412.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002A-C62C-3 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002A-C62D-1
Genre: Journal Article
Alternative Title : Restoration of spatial working memory by genetic rescue of GluR-A-deficient mice

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NatNeurosci_8_2005_270.pdf (Any fulltext), 238KB
 
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 Creators:
Schmitt, Wolfram B., Author
Sprengel, Rolf1, Author           
Mack, Volker1, Author           
Draft, Ryan1, Author           
Seeburg, Peter H.1, Author           
Deacon, Robert M. J., Author
Rawlins, John Nicholas P., Author
Bannerman, David M., Author
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1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: Gene-targeted mice lacking the AMPA receptor subunit GluR-A (also called GluR1 encoded by the gene Gria1,) have deficits in hippocampal CA3-CA1 long-term potentiation (LTP) and have profoundly impaired hippocampus-dependent spatial working memory (SWM) tasks, although their spatial reference memory remains normal. Here we show that forebrain-localized expression of GFP-tagged GluR-A subunits in GluR-A-deficient mice rescues SWM, paralleling its rescue of CA3-CA1 LTP. This provides powerful new evidence linking hippocampal GluR-A-dependent synaptic plasticity to rapid, flexible memory processing.

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Language(s): eng - English
 Dates: 2004-09-292005-01-242005-02-202005-03-01
 Publication Status: Issued
 Pages: 3
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 665657
DOI: 10.1038/nn1412
URI: http://www.ncbi.nlm.nih.gov/pubmed/15723058
URI: http://www.nature.com/neuro/journal/v8/n3/full/nn1412.html
Other: 6319
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Title: Nature Neuroscience
  Other : Nat. Neurosci.
Source Genre: Journal
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Publ. Info: New York, NY : Nature America Inc.
Pages: - Volume / Issue: 8 (3) Sequence Number: - Start / End Page: 270 - 272 Identifier: ISSN: 1097-6256
CoNE: https://pure.mpg.de/cone/journals/resource/954925610931