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  Enhanced odor discrimination and impaired olfactory memory by spatially controlled switch of AMPA Receptors

Shimshek, D. R., Bus, T., Kim, J.-H., Mihaljevic, A., Mack, V., Seeburg, P. H., et al. (2005). Enhanced odor discrimination and impaired olfactory memory by spatially controlled switch of AMPA Receptors. PLoS Biology, 3(11): 354, pp. 2017-2030. doi:10.1371/journal.pbio.0030354.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-CAD3-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-CAD4-B
Genre: Journal Article
Alternative Title : Enhanced odor discrimination and impaired olfactory memory by spatially controlled switch of AMPA Receptors

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 Creators:
Shimshek, Derya R.1, Author              
Bus, Thorsten2, Author              
Kim, Jin-Hyun, Author
Mihaljevic, André1, Author              
Mack, Volker1, Author              
Seeburg, Peter H.1, Author              
Sprengel, Rolf1, Author              
Schaefer, Andreas T.2, 3, Author              
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Max Planck Research Group Behavioural Neurophysiology (Andreas T. Schaefer), Max Planck Institute for Medical Research, Max Planck Society, ou_1497722              
3Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Abstract: Genetic perturbations of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) are widely used to dissect molecular mechanisms of sensory coding, learning, and memory. In this study, we investigated the role of Ca2+-permeable AMPARs in olfactory behavior. AMPAR modification was obtained by depletion of the GluR-B subunit or expression of unedited GluR-B(Q), both leading to increased Ca2+ permeability of AMPARs. Mice with this functional AMPAR switch, specifically in forebrain, showed enhanced olfactory discrimination and more rapid learning in a go/no-go operant conditioning task. Olfactory memory, however, was dramatically impaired. GluR-B depletion in forebrain was ectopically variable ("mosaic") among individuals and strongly correlated with decreased olfactory memory in hippocampus and cortex. Accordingly, memory was rescued by transgenic GluR-B expression restricted to piriform cortex and hippocampus, while enhanced odor discrimination was independent of both GluR-B variability and transgenic GluR-B expression. Thus, correlated differences in behavior and levels of GluR-B expression allowed a mechanistic and spatial dissection of olfactory learning, discrimination, and memory capabilities.

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Language(s): eng - English
 Dates: 2005-05-062005-08-162005-10-182005-11-01
 Publication Status: Published in print
 Pages: 14
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 Table of Contents: -
 Rev. Method: Peer
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Title: PLoS Biology
  Other : PLoS Biol.
Source Genre: Journal
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Publ. Info: Public Library of Science
Pages: - Volume / Issue: 3 (11) Sequence Number: 354 Start / End Page: 2017 - 2030 Identifier: ISSN: 1544-9173
CoNE: /journals/resource/111056649444170