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  Cell-targeted optogenetics and electrical microstimulation reveal the primate koniocellular projection to supra-granular visual cortex

Klein, C., Evrard, H. C., Shapcott, K. A., Haverkamp, S., Logothetis, N. K., & Schmid, M. (2016). Cell-targeted optogenetics and electrical microstimulation reveal the primate koniocellular projection to supra-granular visual cortex. Neuron, 90(1), 143-151. doi:10.1016/j.neuron.2016.02.036.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002A-E135-E Version Permalink: https://hdl.handle.net/21.11116/0000-000C-177D-F
Genre: Journal Article

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Klein_2016_Cell-TargetedOptogenetics.pdf (Publisher version), 2MB
 
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Klein_2016_Cell-TargetedOptogenetics.pdf
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2016
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Copyright © 2016 Elsevier Inc.
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https://www.sciencedirect.com/science/article/pii/S0896627316001732 (Publisher version)
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 Creators:
Klein, Carsten1, Author
Evrard, Henry C., Author
Shapcott, Katharine A.1, Author
Haverkamp, Silke, Author
Logothetis, Nikos K., Author
Schmid, Michael1, Author           
Affiliations:
1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstr. 46, 60528 Frankfurt, DE, ou_2074314              

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Free keywords: Animals Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism Electric Stimulation Geniculate Bodies/metabolism/*physiology Macaca fascicularis Macaca mulatta Male Neural Pathways/physiology Neurons/*physiology Optogenetics Visual Cortex/*physiology
 Abstract: Electrical microstimulation and more recently optogenetics are widely used to map large-scale brain circuits. However, the neuronal specificity achieved with both methods is not well understood. Here we compare cell-targeted optogenetics and electrical microstimulation in the macaque monkey brain to functionally map the koniocellular lateral geniculate nucleus (LGN) projection to primary visual cortex (V1). Selective activation of the LGN konio neurons with CamK-specific optogenetics caused selective electrical current inflow in the supra-granular layers of V1. Electrical microstimulation targeted at LGN konio layers revealed the same supra-granular V1 activation pattern as the one elicited by optogenetics. Taken together, these findings establish a selective koniocellular LGN influence on V1 supra-granular layers, and they indicate comparable capacities of both stimulation methods to isolate thalamo-cortical circuits in the primate brain.

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 Dates: 2016-03-242016-04-06
 Publication Status: Issued
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 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.neuron.2016.02.036
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Title: Neuron
  Alternative Title : Neuron
Source Genre: Journal
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Pages: - Volume / Issue: 90 (1) Sequence Number: - Start / End Page: 143 - 151 Identifier: ISBN: 1097-4199 (Electronic)0896-6273 (Linking)