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  Comparative study of wound healing in rat skin following incision with a novel picosecond infrared laser (PIRL) and different surgical modalities

Petersen, H., Tavakoli, F., Kruber, S., Münscher, A., Gliese, A., Hansen, N.-O., et al. (2016). Comparative study of wound healing in rat skin following incision with a novel picosecond infrared laser (PIRL) and different surgical modalities. Lasers in Surgery and Medicine, 48(4), 385-391. doi:10.1002/lsm.22498.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-E083-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-DCF3-5
Genre: Journal Article

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Petersen_et_al-2016-Lasers_in_Surgery_and_Medicine.pdf (Publisher version), 893KB
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Petersen_et_al-2016-Lasers_in_Surgery_and_Medicine.pdf
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This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
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2016
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http://dx.doi.org/10.1002/lsm.22498 (Publisher version)
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 Creators:
Petersen, Hannes1, Author
Tavakoli, Fatemeh1, Author
Kruber, Sebastian2, Author              
Münscher, Adrian1, Author
Gliese, Alexandra1, Author
Hansen, Nils-Owe2, Author              
Uschold, Stephanie2, 3, Author              
Eggert, Dennis4, Author
Robertson, Wesley2, Author              
Gosau, Tobias5, Author
Sehner, Susanne6, Author
Kwiatkowski, Marcel7, Author
Schlüter, Hartmut7, Author
Schumacher, Udo5, Author
Knecht, Rainald1, Author
Miller, R. J. Dwayne2, Author              
Affiliations:
1Department of Otorhinolaryngology, Head and Neck Surgery and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ou_persistent22              
2Miller Group, Atomically Resolved Dynamics Department, Max Planck Institute for the Structure and Dynamics of Matter, Max Planck Society, ou_1938288              
3International Max Planck Research School for Ultrafast Imaging & Structural Dynamics (IMPRS-UFAST), Max Planck Institute for the Structure and Dynamics of Matter, Max Planck Society, ou_2266714              
4Heinrich-Pette-Institute, Leibnitz Institute of Experimental Virology, Hamburg, Germany, ou_persistent22              
5Department of Anatomy and Experimental Morphology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ou_persistent22              
6Department of Medical Biometry and Epidemiology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany, ou_persistent22              
7Department of Clinical Chemistry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ou_persistent22              

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Free keywords: animal model; electrosurgical device; electrosurgery; histology; laser surgery; scalpel
 Abstract: Background and Objective: As a result of wound healing the original tissue is replaced by dysfunctional scar tissue. Reduced tissue damage during surgical procedures beneficially affects the size of the resulting scar and overall healing time. Thus the choice of a particular surgical instrument can have a significant influence on the postoperative wound healing. To overcome these problems of wound healing we applied a novel picosecond infrared laser (PIRL) system to surgical incisions. Previous studies indicated that negligible thermal, acoustic, or ionization stress effects to the surrounding tissue results in a superior wound healing. Study Design/Materials and Methods: Using the PIRL system as a surgical scalpel, we performed a prospective wound healing study on rat skin and assessed its final impact on scar formation compared to the electrosurgical device and cold steel. As for the incisions, 6 full-thickness, 1-cm long-linear skin wounds were created on the dorsum of four rats using the PIRL, an electrosurgical device, and a conventional surgical scalpel, respectively. Rats were euthanized after 21 days of wound healing. The thickness of the subepithelial fibrosis, the depth and the transverse section of the total scar area of each wound were analyzed histologically. Results: After 21 days of wound healing the incisions made by PIRL showed minor scar tissue formation as compared to the electrosurgical device and the scalpel. Highly significant differences (P < 0.001) were noted by comparing the electrosurgical device with PIRL and scalpel. The transverse section of the scar area also showed significant differences (P = 0.043) when comparing PIRL (mean: 141.46 mm2; 95%CI: 105.8–189.0 mm2) with scalpel incisions (mean: 206.82 mm2; 95%CI: 154.8–276.32 mm2). The subepithelial width of the scars that resulted from using the scalpel were 1.3 times larger than those obtained by using the PIRL (95%CI: 1.0–1.6) though the difference was not significant (P < 0.083). Conclusions: The hypothesis that PIRL results in minimal scar formation with improved cosmetic outcomes was positively verified. In particular the resection of skin tumors or pathological scars, such as hypertrophic scars or keloids, are promising future fields of PIRL application.

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Language(s): eng - English
 Dates: 2016-02-192016-03-04
 Publication Status: Published online
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/lsm.22498
 Degree: -

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Project name : Contract grant sponsor: European Research Council; Contract grant number: ERC-AdG-2011-291630.
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Title: Lasers in Surgery and Medicine
  Abbreviation : Lasers Surg Med
Source Genre: Journal
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Publ. Info: Hoboken, NJ, USA : John Wiley & Sons
Pages: - Volume / Issue: 48 (4) Sequence Number: - Start / End Page: 385 - 391 Identifier: ISSN: 1096-9101
CoNE: /journals/resource/1096-9101