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  Generalizing the concept of specific compound formulation additives towards non-fluorescent drugs : a solubilization study on potential anti-Alzheimer-active small-molecule compounds

Lawatscheck, C., Pickhardt, M., Wieczorek, S., Grafmüller, A., Mandelkow, E., & Börner, H. G. (2016). Generalizing the concept of specific compound formulation additives towards non-fluorescent drugs: a solubilization study on potential anti-Alzheimer-active small-molecule compounds. Angewandte Chemie International Edition, 55(30), 8752-8756. doi:10.1002/anie.201601147.

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 Creators:
Lawatscheck, Carmen, Author
Pickhardt, Marcus, Author
Wieczorek, Sebastian, Author
Grafmüller, Andrea1, Author           
Mandelkow, Eckhard, Author
Börner, Hans G., Author
Affiliations:
1Andrea Grafmüller, Theorie & Bio-Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863323              

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Free keywords: Alzheimer's disease, bioconjugates, combinatorial screening, precision polymers, Tau protein
 Abstract: Tailor-made compound formulation additives enable the testing of potential drugs with undesirable pharmacological profiles. A combinatorial approach using Raman microscopy as the readout method is presented to select peptide sequences from large one-bead-one-compound libraries. The resulting peptide–PEG conjugates solubilize potential prophylactic and therapeutic anti-Alzheimer compounds and can be used as specific additives not only for fluorescent but also for non-fluorescent compounds.

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 Dates: 2016-06-102016
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: DOI: 10.1002/anie.201601147
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Title: Angewandte Chemie International Edition
  Other : Angewandte Chemie, International Edition
  Abbreviation : Angew. Chem. Int. Ed.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 55 (30) Sequence Number: - Start / End Page: 8752 - 8756 Identifier: ISSN: 1433-7851